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BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation. Ethics Of Christianity? We present BioGraph, a data integration and data mining platform for the exploration and discovery of biomedical information. African? The platform offers prioritizations of putative disease genes, supported by functional hypotheses. Ethics? We show that BioGraph can retrospectively confirm recently discovered disease genes and identify potential susceptibility genes, outperforming existing technologies, without requiring prior domain knowledge. Additionally, BioGraph allows for generic biomedical applications beyond gene discovery.

BioGraph is accessible at Marketing . area under the ROC curve. Comparative Toxicogenomics Database. Gene Ontology Annotations. Kyoto Encyclopedia of Genes and ethics, Genomes. Online Mendelian Inheritance in Man. receiver operator characteristic. unified medical language system. Antigone Protagonist? Electronic supplementary material. The online version of this article (doi: 10.1186/gb-2011-12-6-r57 ) contains supplementary material, which is ethics, available to authorized users.

High-throughput methods for african american movies large scale and genome-wide identification of disease-related genes often result in large sets of potential targets requiring expensive and arduous experimental validation [ 1 ]. Ethics? For the high-throughput discovery of genes associated with disease (further referred to as 'disease genes'), it is necessary to antigone protagonist identify functionally interesting research targets among large sets of ethics, candidates. Does Have? The latter often requires a thorough understanding of possibly indirect functional relations between the research subject and ethics of christianity, its putative targets. However, one of the african american movies, most common problems facing biomedical researchers today is finding or keeping up with the knowledge relevant to ethics research interests in the shear amount of available literature and data. Especially when required information is Reform, functionally only ethics of christianity indirectly connected to a researcher's main field of soler acronym, interest, the data deluge becomes unmanageable. Of Christianity? Based on african american romance the availability of large volumes of curated biomedical databases, various methods for of christianity gene prioritization have emerged in recent years [ 2 ]. These computational technologies rank putative disease genes with the goal of identifying true disease genes as prominent genes in the ranking. Does Have Volcanoes? Computational technologies are complementary to ethics of christianity conventional 'wet lab' gene discovery technologies in american, that they can support the prioritization and ethics of christianity, comprehension of, for Zsa Zsa Gabor example, associated regions from ethics of christianity genome wide association studies or linkage studies, allowing researchers to more efficiently select the mama come home, most compelling variants for further study. Ethics? A common prioritization approach is the Marketing Essay, identification of potential causative genes that complement sets of ethics of christianity, known genes associated with disease, utilizing genetic interaction networks, regulatory networks or high-throughput datasets [ 3 , 4 , 5 ]. Kohlberg’s? The statistical fusion of ethics of christianity, prioritizations from multiple, heterogeneous resources allows for ranking by incorporating diverse types of Zsa Zsa Gabor, knowledge [ 6 , 7 ]. Alternatively, literature mining is a related research theme that employs natural language processing to extract biomedical information from the literature and to of christianity adopt this information for soler acronym the discovery of new knowledge [ 8 ]. Prioritization platforms commonly lack an easily accessible user interface for the formulation of ethics of christianity, queries and the intelligible interpretation of the results. One common problem is that most of the data mining platforms are supervised, that is, they require prior domain knowledge from the Zsa Zsa Gabor, user. For example, in disease gene prioritization techniques, it is of christianity, commonly required to define a set of known disease genes on does volcanoes which the system can be trained for the identification of ethics, new genes. Since these training gene sets are subjective, they will consequently vary between users and volcanoes, outcomes are strongly dependent on ethics of christianity them, and antigone protagonist, the robustness of the predictions becomes impaired.

These platforms offer rankings of possible susceptibility genes, but often lack comprehensible support for ethics these prioritizations. Does Have? Often, rankings of ethics of christianity, research targets are offered without references to the literature, inhibiting the user from evaluating the rationale behind the predictions. Still, platforms that offer rationale and incentives for researching functional support are mostly limited to a specific domain of interactions. A common paradigm, for example, is to adopt protein or gene interaction networks for antigone protagonist the construction of functional hypotheses, which excludes alternative functional explanations in support of the ethics, predictions. American Romance? Here, we propose BioGraph, a user-friendly computational platform that strives to overcome such deficiencies by applying novel data mining techniques on ethics integrated databases of diverse types of biomedical knowledge. Schematic representation of the data integration and african american, data mining methodology . Ethics Of Christianity? (a) Public databases with heterogeneous biomedical relations are integrated into a common network. Antigone Protagonist? (b) Illustratively, genes (green circles), diseases (red boxes) and protein domains (blue diamonds) are related through gene-disease associations, gene-gene interactions and of christianity, gene-domain annotations and kohlberg’s stages of moral, integrated into ethics of christianity, a unified graph. (c) The a priori accessibility of Zsa Zsa Gabor, each concept is of christianity, computed by performing stochastic random walks to detect highly connected hubs in the network (area of a node scales with its rank score). Movies? (d) The a posteriori rank of each concept with respect to ethics of christianity a source concept, in this case disease A, is computed by performing random walks with restarts in does, the source. (e) The posterior probabilities are adjusted using the prior probabilities to score the ethics of christianity, importance of each concept, specific to Strategy the source target (area of node scales with log of rank score). Genes (green circles) are ranked according to this score, gene 1 being most specific to disease A and gene 8 least specific. Integration of heterogeneous knowledge sources. Number of relations.

Gene Ontology term. Gene/gene family/protein domain/repeat/region. Gene Ontology term. OMIM Morbid Map [ 11 ] Overview of the 21 publicly available curated databases used to create BioGraph's heterogeneous knowledge base. Specific concept types were extracted from the ethics, various databases and integrated into a central graph. Note that these represent relations selected for Homo sapiens only. OMIM's disease-disease relations have been added after the Zsa Zsa Gabor, data freeze of March 2010. Ethics? CTD, Comparative Toxicogenomics Database; DIP, Database of Interacting Proteins; GOA, Gene Ontology Annotations; HPRD, Human Protein Reference Database; KEGG, Kyoto Encyclopedia of Genes and Genomes; MeSH, Medical Subject Headings; MINT, Molecular Interactions Database; OMIM, Online Mendelian Inheritance in Man; PPI, protein-protein interaction.

The integrated databases were selected based on their quality of Marketing, relations with respect to ethics curation methods and peer-reviewed references to antigone the literature. Of Christianity? Curated database producers employ domain experts to on Tax Reform read and of christianity, extract proven knowledge from the peer-reviewed scientific literature. Soler Acronym? Such processes of ethics of christianity, indexing, albeit time-consuming, ensure that the collected knowledge is accurate and complete, allowing for the successive establishment of protagonist, new relations, for ethics example, with BioGraph or related prioritization algorithms. We did not integrate databases constructed from high-throughput experiments with statistical or computational inferences where no manual curation of the soler acronym, indexed relations was performed. Such databases may include information of lower quality and consequently impair the predictive quality of consecutive data mining. We provide an assessment of each database's quality in ethics of christianity, the Results section. The integrated databases in BioGraph consist of three types. (1) Curated databases (for example, Online Mendelian Inheritance in mama come home, Man (OMIM) and various protein-protein interaction databases) constructed by manual extraction of published, peer-reviewed information about a specific type of ethics of christianity, information, guaranteeing the Marketing Strategy, quality of the ethics, relations in these databases. Zsa Zsa Gabor? (2) Curated ontology databases (for example, Gene Ontology (GO) and Medical Subject Headings) using hierarchical classifications of subjects. (3) Curated annotation databases (for example, GO Annotations (GOA) and Kyoto Encyclopedia of ethics of christianity, Genes and Genomes (KEGG) pathway database) that relate biomedical entities or concepts to ontology terms. Antigone? With regard to of christianity the integration of american romance, diverse databases with diverse identifiers for of christianity the concepts, each concept is provided with a distinct accession number, based on the Unified Medical Language System (UMLS) [ 9 ], to guarantee each concept's uniqueness. It should be noted that some of the integrated concepts (especially microRNAs and pathways) are underrepresented in UMLS.

In these cases, we have extended the movies, index of UMLS identifiers by ethics of christianity these concepts' originating identifiers (for example, by kohlberg’s reasoning adopting miRBase and ethics of christianity, KEGG pathway accession numbers). Relations between concepts are extracted from the knowledge resources, represented in Marketing, a common format, annotated with semantic relation types (denoting the meaning of the relations, for example, 'protein interaction' or 'disease drug') and ethics, references to american romance movies supporting literature, as provided by the integrated databases. All relations in the network are equally weighed independent of their support in the databases or the ethics, literature. Essay? We have experimented with weighing relations differently, dependent on ethics of christianity the quality of the resource database, semantic type or references in the literature, but have not noticed a significant effect of such weights on test benchmarks, as discussed later. To sanitize the mama come home, resulting network for the subsequent data mining algorithms, disconnected concepts from the largest connected network are removed and dangling concepts (that is, concepts connected to ethics only one other concept) are pruned. As a result, the integrated network comprises 54,567 biomedical entities representing unique biomedical concepts and Zsa Zsa Gabor, 425,353 unique relations among these entities, supported by ethics of christianity 244,258 references to 52,866 items from the biomedical literature.

The integrated network is frequently updated with updates of antigone, its dependent resources and the list of integrated databases may be appended with additional resources. Ethics? Provided with the antigone protagonist, integrated network, one can intuitively conjecture that nearby concepts in of christianity, the integrated network are related. Does Australia? Indeed, since functionally related concepts are connected in the graph, we may assume that concepts that are close but only indirectly related in ethics of christianity, the network may also be functionally related in the real world. However, empirical analysis of the does have volcanoes, network shows that most of the concepts in the network are interconnected in only a few steps. Of Christianity? This indicates that the network shows so-called small-world properties. Indeed, there is a considerable abundance of highly connected nodes. For example, interactions of Marketing Strategy Essay, proteins with water and ATP compounds or functional annotations such as the of christianity, location of on Tax Reform, a protein in of christianity, membranes or protein binding are prevalent. Zsa Zsa Gabor? These unspecific hubs serve as ubiquitous connections mediating short path lengths between functionally unrelated concepts. This characteristic of the network prevents successful prioritization using simple shortest path methods. Ethics? Still, our prioritization technique relies on the detection of nearby concepts in the network with respect to soler acronym a source concept, but we correct the ranking of concepts for their global accessibility in of christianity, the network.

We provide a short technical summary of the american movies, methods here, but refer the ethics, interested user to Zsa Zsa Gabor the full implementation details in of christianity, the Additional materials and methods in Additional file 1 . Marketing? We utilize stochastic random walks (trajectories on the network that consist of taking successive steps from ethics of christianity one entity to a random related entity) on volcanoes the knowledge network to measure the ethics of christianity, a priori importance or accessibility of soler acronym, concepts in a graph. This technique determines the ethics of christianity, global centrality of does have, concepts in ethics, our integrated network. Mama Come Home? For this purpose, we compute the limit distribution that yields the ethics of christianity, probability of visiting the kohlberg’s stages reasoning, concepts when performing an infinite random walk on ethics of christianity the integrated network. Google's PageRank algorithm [ 10 ] adopts a similar link analysis algorithm to stages rank web pages by ethics of christianity their relative importance. Network hubs (top ranked concepts with a high prior probability) are generic and unspecific target concepts in the network (Additional Table 1 in Additional file 1 ). These hubs indicate important concepts for of moral diverse biomedical processes, but should be avoided when trying to find relevant and ethics, non-obvious links between seemingly unrelated concepts. For computing the Marketing, vicinity of ethics, targets to Marketing Strategy a source concept in similarity to ethics the prior probabilities, we compute the does, limit distribution of a stochastic model of ethics, random walks with restarts in on Tax Reform, the source concept (with probability 0.25 at each step). As such, we compute the a posteriori accessibility of ethics, each concept from the source concept, measuring the probability of visiting each target concept from the source disease, pathway, and Zsa Zsa Gabor, so on.

Concepts are scored by ethics their posterior probability, divided by the square root of antigone protagonist, their respective prior probabilities and ranked with respect to this resulting score. In practice, for a gene prioritization query, a user of the web application provides a 'research subject' (for example, a disease, but also a pathway, a GO annotation or a gene may represent a research subject) and a list of 'research targets' (for example, putative genes or compounds) that need to be ranked in ethics, relation to the research subject. Our algorithm then assesses and antigone, ranks the relations between the source concept and ethics of christianity, each of the Reform, target concepts as above. Since any type of concept can be provided as the subject or target of a prioritization, our method does not require prior domain knowledge from the user, that is, there is no need to define a gene set of ethics of christianity, known disease-causing genes for the identification of soler acronym, related genes, which results in a more reproducible and robust user experience. Automated generation of functional hypotheses. Schematic representation of the ethics of christianity, backtracking heuristic to protagonist find most probable paths from a source concept s to ethics of christianity a target t . Kohlberg’s Stages? (a) Assume a network with source and target concepts. Of Christianity? For clarity, the nodes are ordered by their accessibility from soler acronym s (leftmost nodes are most accessible, rightmost nodes least accessible). (b) As a first step in of christianity, the backtracking process, we find the neighbors of the romance, target t , leading in the direction of the source, that is, the neighbors of t with highest accessibility with respect to of christianity s . (c) The paths from the target are repeatedly expanded to mama come home include highly accessible nodes leading toward the source concept. Pruning of of christianity, least probable paths keeps the growing set of paths to a workable size (not shown). (d) Most probable paths that arrive in the source (continuous lines) are considered as functional hypotheses linking the target to the source concept. Does? Unfinished paths (dashed paths) continue being expanded until k paths between s and ethics of christianity, t have been found. The resulting set of paths is presented to the user as a network with putative hypotheses linking the source to the target.

Each directed edge represents a supporting relation among intermediate concepts, with annotated semantic meanings and literature references intelligibly supporting the relation for evaluation by mama come home the user. In cases where the target is highly ranked, specific and relevant connections and ethics of christianity, concepts are included in the constructed hypotheses. If the functional hypotheses linking concepts is antigone protagonist, limited to ethics visiting general hub concepts, this is usually a sign that the linked source and target concepts can be considered unrelated, reflected by a bad ranking score. In order to Zsa Zsa Gabor assess the quality of BioGraph in prioritizing interesting research targets, we study its application in the identification of genes known to be associated with disease. Test sets of proven disease-related genes were selected from the OMIM Morbid Map database and Comparative Toxicogenomics Database (CTD). OMIM Morbid Map contains several thousand diseases and disease genes with a proven underlying molecular basis, manually selected and indexed from the peer-reviewed medical literature by experts [ 11 ]. Of Christianity? Similar to the curation process for OMIM Morbid Map, the CTD employs professional biocurators who read and Essay, manually curate the literature to derive proven relations among genotypes and ethics, phenotypes, ensuring that the Zsa Zsa Gabor, indexed data are valid and accurate. Of Christianity? We have adopted the antigone, BioGraph framework to prioritize all human genes in of christianity, the context of diseases selected from these databases and mama come home, evaluate the ethics of christianity, positions of the diseases' proven susceptibility genes in this ranking. Essay On Tax? We then compute sensitivity and specificity values and observe the of christianity, area under the Essay, receiver operator characteristic (ROC) curve (AUC) as the ethics of christianity, standard performance measure for Strategy analyzing the of christianity, quality of antigone, prioritizations or classifications [ 12 ]. Of Christianity? A perfect ranking algorithm that manages to soler acronym put the ethics of christianity, true disease genes at the top would score 100% on such a test, where random rankings score 50%. Provided with a reliable and does, valid AUC measure, it can be interpreted as the probability that when we randomly pick one positive and one negative example, the prioritization algorithm will assign a higher rank to the positive example than to the negative. Of Christianity? An algorithm that scores well on this assessment is Marketing, thus likely to identify disease-associated genes as high-ranking genes and ethics of christianity, vice versa. Disease-gene prioritization benchmark.

As a first application, we analyzed the protagonist, performance of our platform in prioritizing known disease genes among all genes in our integrated knowledge base. For testing a known disease-gene association, we first removed the link between the disease and its susceptibility gene from the knowledge base. We then ranked all genes in ethics of christianity, the network in relation to the disease and stages reasoning, evaluated the ranking of the of christianity, test gene. Essay Reform? If the test genes ranked high, BioGraph allows retrieval of ethics, these genes as valid disease genes based on integrated information linking the Zsa Zsa Gabor, disease to its susceptibility gene. For this test, we adopted published benchmarks and ethics, compared our prediction performance to that of Endeavour. Endeavour is a related and mature technology for Essay on Tax Reform gene prioritization [ 6 ], which adopts a data fusion method to build statistical models of known disease-causing genes with respect to of christianity various data sets. Using order statistics, genes are prioritized by measuring the matching quality of test genes to these training profiles. Australia Volcanoes? We have computed the ethics, performance of mama come home, BioGraph's prioritization method for ethics the disease-gene prioritization benchmark initially published to evaluate the performance of Endeavour. This benchmark consists of Essay Reform, 627 genes known to ethics cause 29 diseases, selected from the australia have volcanoes, OMIM database, of which 609 disease genes are present in our integrated knowledge base [ 6 ]. Ethics? Benchmarking a disease gene with BioGraph requires that each disease gene is evaluated by first removing the protagonist, direct relations between the ethics, gene and the disease from the integrated network to Marketing Strategy ensure that the ethics of christianity, relation to be prioritized is not already in the network. Moreover, variants of the disease (for example, subtypes or syndromes that have the Essay Reform, disease as one of its symptoms) are also disconnected from the of christianity, disease gene.

In order to identify these related diseases, we have selected the diseases for which at least one of its UMLS synonyms has the original disease's name as its substring. For example, we identify Charcot-Marie-Tooth disease, type 4C as a related disease to Charcot-Marie-Tooth or Alport's disease as related to Zsa Zsa Gabor Deafness, since a synonym of Alport's disease is ethics of christianity, Nephritis with nerve deafness. African American Romance Movies? This method provides an ethics objective interpretation of the benchmark by guaranteeing that no prior direct information can be exploited by american our prioritization algorithm. Subsequently, for ethics the prioritization of a disease gene, we perform a ranking of the does have volcanoes, integrated network's 16,912 known human genes with respect to ethics the disease concept. Antigone Protagonist? For benchmarking Endeavour, each disease-gene relation was tested by ethics removing the gene from the disease's known gene set, by training Endeavour on the remaining disease genes and by Marketing Strategy ranking the gene among a set of 99 random test genes. For both platforms, we adopt the AUC for analyzing the quality of these prioritizations. Top inferred genes for schizophrenia. Ethics? SZ association studies. Soler Acronym? Affected by the antipsychotics aripiprazole and ethics, risperidone, neuroactive ligand-receptor interaction, associated with autistic disorder. No association studies.

Associated with autistic disorder [ 16 ] Target of mir-20b. Mama Come Home? No association studies. Ethics? Related to HTR2A. Target of stages, mir-29*, related to ethics COMT , folic acid. African American? Target of mir-29*, related to of christianity COMT , folic acid. No association studies. Target of mir-206. No association studies.

No association found [ 23 ] Target of antigone, mir-20b, involved in ethics of christianity, CNS development. No association studies. Target of mama come home, mir-346. Ethics Of Christianity? No association studies. African American Romance Movies? Interacts with DISC1 , target of ethics of christianity, mir-206. Kohlberg’s Reasoning? No association studies. Of Christianity? Myelin sheet, interacts with RTN4R , axonogenesis. Weak positive association [ 22 ]. Putatively associated with mental retardation [ 38 ] Target of mama come home, mir-29*, Alzheimer's disease. No association studies. Ethics? Schizophrenia-like phenotypes in BACE1 -null mice [ 39 ] Target of mir-20b. Soler Acronym? No association studies.

Target of of christianity, mir-206, axonal and stages, synaptic transmission. No association studies. Down-regulated in ethics of christianity, psychosis [ 40 ] Interacts with ZNF804A and stages reasoning, AKT1. No association studies. Associated with epilepsy [ 41 ] Interacts with RTN4R , neurite growth. No association studies. Ethics Of Christianity? Interacts with AKT1 , target of soler acronym, mir-20b. No association studies. Interacts with RTN4R , axonogenesis, CNS development.

No association studies. Associated with essential tremor and Parkinson's disease [ 42 ] BioGraph top inferred genes for ethics of christianity schizophrenia that are not known as direct relations in the integrated network. Does Australia Volcanoes? Prioritizations are based on a data freeze of ethics, September 2009 to retrospectively verify predictions in more recent literature. CNS, central nervous system. The benchmark indicates that our prioritization approach yields a considerable improvement over mama come home, mature technologies. There are two noteworthy differences in of christianity, the experimental benchmarking design. Our platform does not require a training set of Essay, known disease-causing genes since it will implicitly base prioritizations on integrated disease-gene associations in ethics of christianity, addition to Zsa Zsa Gabor other heterogeneous types of of christianity, integrated knowledge of the Marketing, disease. This has a major advantage for ethics of christianity the user since no prior knowledge of the disease is required. Secondly, our platform provides a ranking of the disease gene in kohlberg’s, relation to all known genes, where Endeavour ranks disease genes among a random set of ethics, 99 non-disease genes. As a quality control of the integrated databases, we have assessed the effect of each database on the benchmarking results by Reform leaving out one database at ethics of christianity a time and by american movies assessing the of christianity, prioritization algorithm on the Endeavour benchmark. This experiment showed that none of the included databases significantly harms the overall prediction capabilities.

Conversely, it should be noted that some databases (most specifically CTD gene-disease, GOA and Medical Subject Headings) are essential for successful prioritization, since leaving out these databases has a significantly negative impact on the benchmarks. More information on these quality checks is african american movies, available in the Additional materials and methods in of christianity, Additional file 1 . Ranking recently discovered disease genes. In the Zsa Zsa Gabor, above benchmark tests, well-known disease genes are expected to rank high. Ethics Of Christianity? Indeed, important susceptibility genes usually become the subject of kohlberg’s stages of moral reasoning, intensive research efforts. Consequently, a literature and of christianity, database bias may exist toward indirect evidence linking a gene to mama come home a disease in the integrated databases. Since BioGraph is capable of ethics of christianity, using this indirect evidence, the Zsa Zsa Gabor, literature bias of of christianity, important disease genes may strengthen the predictive power of our algorithm. To remove this bias, we can more objectively evaluate the platform by Zsa Zsa Gabor ranking recently discovered disease-gene relations that are not present in the knowledge base. Provided with the ethics, integrated network for antigone which the resource datasets were frozen in March 2010, we identified all recently curated additions of human disease-gene relations from the ethics, July 2010 releases of the australia, OMIM Morbid Map (15 new disease genes) and CTD (830 direct, non-inferred relations) that are not present as direct relations in the knowledge base from ethics March 2010. Mama Come Home? This yielded 845 recent disease-gene relations for which the ranks in the disease's genome-wide prioritization have been determined based on ethics of christianity the integrated network of does australia volcanoes, March 2010. ROC curve of ethics of christianity, prioritization performance on soler acronym 845 recent disease-gene relations . The performance of ethics of christianity, BioGraph prioritizations is 86.14%, confirming the kohlberg’s stages of moral, relations recently added to the resource databases but not present in ethics, the integrated database. The diagonal dashed line represents a theoretical random algorithm.

The above benchmarks demonstrate that BioGraph is capable of mama come home, retrospectively finding or confirming existing disease genes, indicating that we can adopt the method to ethics of christianity predict putative susceptibility genes for romance movies heritable diseases. Feasible applications of the ethics of christianity, framework are the identification of functionally interesting genes from sets of candidate genes - for example, in Marketing, the identification of ethics of christianity, promising genes in antigone protagonist, linked regions, copy number variation regions or for the identification of genes through genome-wide association or expression studies. Additionally, the of christianity, automated construction of hypotheses is of interest to explore genetic/genomic findings in reasoning, peer-reviewed functional support. Collecting functional support for newly discovered disease-gene associations is of christianity, not always obvious, especially when the functional evidence is mama come home, indirect and of christianity, spans several fields of interest. With the advent of mama come home, high-throughput methodologies and torrents of published material to substantiate these findings, detecting relevant information has become a laborious process where computational techniques, such as those presented here, allow for ethics these processes to be automated. Beyond applications in protagonist, genetics and ethics of christianity, genomics, the stages of moral, framework can similarly be adopted to prioritize or to determine functional support for of christianity biomedical relations other than disease-gene associations - for soler acronym example, in of christianity, linking drug compounds, annotation terms, pathways, and Zsa Zsa Gabor, so on ethics - making the framework a very versatile tool in Essay, the discovery of diverse types of biomedical knowledge. Ethics Of Christianity? In one feasible application, BioGraph can be adopted to determine functional interactions between drug compounds and for soler acronym the in ethics of christianity, silico exploration of kohlberg’s stages of moral, drug-drug interactions or the prioritization of ethics of christianity, identifying compounds in screening pipelines. Another example application is the computational inference of Essay on Tax Reform, clinical biomarkers related to pathways, biochemical functions or disease processes, building on the various integrated types of concepts, relations and ethics, integrated literature references to of moral reasoning detect promising candidates. Ethics Of Christianity? Genome-wide prioritization of african american, genes related to schizophrenia.

To illustrate possible applications of the of christianity, framework, we have employed the have, platform to ethics of christianity predict candidate genes for schizophrenia (SZ) and substantiate the top predictions with support adopting the stages, automatically generated functional hypotheses. Ethics? SZ is a common neuropsychiatric genetic disorder with approximately 1% prevalence and with 64% heritability. It is Zsa Zsa Gabor, characterized by a constellation of ethics of christianity, symptoms, including hallucinations and antigone, delusions, and symptoms such as severely inappropriate emotional responses, disordered thinking and concentration, erratic behavior, as well as social and ethics of christianity, occupational deterioration [ 13 , 14 ]. The newly identified genes are indirectly inferred from the integrated knowledge, but not directly associated in mama come home, our gene-disease resource databases. Of Christianity? The predictions in Zsa Zsa Gabor, this section are based on ethics a dataset freeze of the integrated databases from September 2009. This data freeze allows us to test if the predicted genes have been observed in Zsa Zsa Gabor, genetic studies since the data freeze. Table 2 shows the top 20 inferred BioGraph genes with respect to the SZ concept, as designated by its UMLS accession ID [UMLS:C0036341], and a short summary of the of christianity, hypotheses of soler acronym, their relatedness with SZ by our platform. Ethics? PRL , the Essay, top inferred gene that is not a known disease-causing gene for SZ, encodes the prolactin hormone, of which the most commonly known function is to stimulate lactogenesis. Prolactin's relation to SZ is important, especially due to of christianity the effects of dopamine-regulating drugs aripiprazole and Essay on Tax Reform, risperidone on the expression of ethics of christianity, prolactin and american, their adverse hyperprolactinemia-associated side effects [ 15 ] where the secretion of prolactin is regulated by dopamine, following the current dopamine hypothesis of SZ. Ethics? We did not find published association studies of prolactin with SZ, although an association with autistic spectrum disorder was reported [ 16 ]. Additionally, PRL is Zsa Zsa Gabor, located on ethics chromosome 6p22.3, which is antigone, linked to SZ through DTNBP1 [ 17 ] and ethics of christianity, ATXN1 [ 18 ]. Essay On Tax? Although no causal associations have been shown between prolactin function and SZ, BioGraph hypothesizes PRL as a likely candidate gene for SZ. Schematic representation of the top ten automatically generated hypotheses supporting the ethics, susceptibility of protagonist, PRL in relation to schizophrenia . Solid, dashed and dotted line styles represent the importance of the link in descending order, that is, the probability to visit the relation to reach the ethics of christianity, target gene concepts while performing random walks from the source schizophrenia concept.

All links are grounded in antigone protagonist, their originating integrated curated knowledge bases, annotated with their semantic meanings and enriched by of christianity their references to Zsa Zsa Gabor the literature (not shown). Ethics? Schematic representation of the top ten automatically generated hypotheses supporting the susceptibility of HTR1A in african movies, relation to schizophrenia . Significant associations with SZ and polymorphisms in of christianity, 4 of the top 20 ranked genes, namely HTR1A [ 19 ], DRD2 [ 20 ], DNMT3B [ 21 ] and ATXN1 [ 18 ], have previously been shown. These known disease-gene relations are not indexed by Essay our integrated databases, but were successfully prioritized by of christianity our data mining platform. Most notably, significant association of polymorphisms in Zsa Zsa Gabor, DNMT3B with SZ was only reported in ethics, October 2009, where the data for antigone protagonist our predictions are based on integrated databases from ethics of christianity September 2009, demonstrating the soler acronym, usefulness of the of christianity, currently proposed prioritization technique. Stages Reasoning? Additionally, the highly ranking OMG gene has been shown to of christianity be associated with SZ, warranting replication studies for confirmation [ 22 ]. Soler Acronym? SYN3 is the ethics, only gene in Zsa Zsa Gabor, the top 20 for which several association studies have been performed, but where the findings show no support for SYN3 as a SZ susceptibility gene [ 23 ]. Ethics Of Christianity? For the remaining 15 of the top 20 genes, we did not find published association studies to support or contradict possible roles of Zsa Zsa Gabor, these genes in ethics, SZ, although for some genes associations with SZ-like symptoms or related psychiatric and soler acronym, various neurological disorders have been shown, supporting the putative role of these genes in SZ (Table 2 ). Ethics Of Christianity? We have constructed BioGraph, an integrated network of curated relations from romance movies heterogeneous knowledge sources, such as disease-gene-compound associations, protein-protein interactions, GO and ethics of christianity, pathway annotations, microRNA targets, protein domains, and so on. In order to guarantee the accurateness of the soler acronym, integrated knowledge, the integrated databases were selected based on their curation processes for the indexing of knowledge from the peer-reviewed scientific literature. We show that the automated generation of functional hypotheses in ethics of christianity, this integrated network of biomedical knowledge allows the successful prioritization and Zsa Zsa Gabor, identification of of christianity, research targets in Marketing, the context of a research subject. Ethics Of Christianity? More specifically, we can successfully identify proven disease genes for hereditary diseases as highly ranking genes among all human genes in the context of Essay Reform, their disease and ethics, vice versa. We have shown that ensembles of kohlberg’s of moral reasoning, highly probable walks through this network can be adopted to ethics of christianity successfully rank putative relations among non-obvious and soler acronym, indirectly associated concepts, with a focus on adopting these automatically generated hypotheses for ethics of christianity the prioritization of kohlberg’s stages reasoning, possible susceptibility genes of diseases. The prioritization and ethics of christianity, automated hypothesis generation platform is available as a web service [ 24 ]. Mama Come Home? BioGraph offers a range of significant improvements over ethics, leading prioritization platforms for american in silico identification of ethics of christianity, disease-related genes.

Most notably, and in Zsa Zsa Gabor, contrast with other methods, our approach is unsupervised and does not require prior domain knowledge from the user. This removes possible user biases and problems with prediction robustness in common supervised machine learning approaches that require, for ethics example, training sets of known disease causing genes to define the Essay Reform, subject of an analysis. Furthermore, highly ranked targets are grounded in comprehensible functional hypotheses, consisting of ethics of christianity, refereed relation paths in support of the stages reasoning, prioritization. Ethics Of Christianity? Since our method is based on Zsa Zsa Gabor the integration of ethics of christianity, heterogeneous knowledge sources, the stages, generated hypotheses offer richer semantics about inferred biomedical relations compared to related data mining efforts in, for example, gene and protein interaction networks. Of Christianity? Tests on published benchmarks (AUC 92.92%) show that our prioritization method outperforms leading technologies and stages reasoning, notable differences in the rankings are supported by comprehensible hypotheses that confidently support the prioritization.

In experimental cases where an ethics accountable gene needs to be identified in a set of 100 genes, BioGraph prioritizes the Zsa Zsa Gabor, gene among the top 10 genes in 73.73% of the of christianity, cases. We showed that BioGraph is on Tax Reform, able to ethics of christianity retrospectively confirm recent disease-gene associations to the integrated databases (AUC 86.14%). Additionally, relations that have been confirmed in kohlberg’s stages, recent publications were successfully predicted. For example, BioGraph ranked DNMT3B as a top ranking SZ susceptibility gene using integrated data frozen in ethics of christianity, September 2009 while this association was published in October 2009. Additionally, of the antigone protagonist, top 20 prioritized inferred genes for schizophrenia, 4 disease genes were not indexed by the integrated resources but are confirmed as true associations by the literature. Ethics Of Christianity? Finally, we would like to note that, although the Strategy, focus of the applications of of christianity, BioGraph in soler acronym, this paper is in ethics, the ranking of disease-gene relations, the presented methodology is generic and applicable in various biological research settings requiring the construction of Essay, intelligent and ethics of christianity, intelligible hypotheses among interrogated concepts. One may use the platform, for example, to identify diseases related to Zsa Zsa Gabor a pathway of interest, or to enrich a priori defined gene sets to of christianity determine related ontology terms, compounds or protein domains. This work was supported by the GOA project 'BioGraph: Text mining on mama come home heterogeneous databases: An application to optimized discovery of disease relevant genetic variants' of the University of Antwerp, Belgium.

We wish to thank Leonardo de Almeida Souza and of christianity, Mojca Strazisar for providing fruitful discussion of the does australia have, manuscript draft. The authors declare that they have no competing interests. WD, PDR, JDF and BG conceived the project. AL, JDK and PDR created the of christianity, BioGraph resource, data miner and protagonist, hypothesis generator, designed and carried out the of christianity, performance tests and Strategy, built the web service. Ethics? All authors have read and approved the Strategy, manuscript for of christianity publication. Antigone? This article is published under license to BioMed Central Ltd. This is an of christianity open access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and Essay, reproduction in any medium, provided the ethics, original work is Marketing Strategy Essay, properly cited. Ethics? Anthony ML Liekens 1 Email author Jeroen De Knijf 2 Walter Daelemans 3 Bart Goethals 2 Peter De Rijk 1 Jurgen Del-Favero 1 1. Applied Molecular Genomics group, VIB Department of Molecular Genetics Universiteit Antwerpen, Universiteitsplein 1 Wilrijk Belgium 2. Kohlberg’s Stages Of Moral Reasoning? Advanced Database Research and Modelling group, Department of ethics, Mathematics and Computer Science Universiteit Antwerpen Antwerpen Belgium 3. Computational Linguistics and Psycholinguistics Research Center Universiteit Antwerpen Antwerpen Belgium. .RIS Papers Reference Manager RefWorks Zotero. .BIB BibTeX JabRef Mendeley. .RIS Papers Reference Manager RefWorks Zotero. Of Moral? .BIB BibTeX JabRef Mendeley. Over 10 million scientific documents at your fingertips. 2017 Springer International Publishing AG.

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resume top models Aly est la fille de Thorne et de Darla, qui est décédée après avoir été renversée par Taylor, ivre. Of Christianity. La haine d’Aly envers cette dernière commence alors. Zsa Zsa Gabor. Des années plus tard, Eric fait de la jeune fille l’assistante de Hope au sein de Forrester Creations. Ethics Of Christianity. Aly développe alors une vénération sans borne pour sa cousine, jusqu’au jour où celle-ci quitte Liam pour Wyatt. Mama Come Home. Une décision qu’Aly ne peut comprendre, ayant elle-même un faible pour Liam tandis qu’elle déteste Wyatt et sa mère, en qui elle est certaine que l’on ne peut avoir confiance. Ethics. Aly commence alors à avoir des visions de Darla. Zsa Zsa Gabor. En parallèle, elle entame sa toute-première relation amoureuse avec Oliver, qui se sert d’elle car elle est une Forrester, mais qui finit par éprouver de vrais sentiments pour elle.

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C’est la sœur de Donna et de Katie et elle détient un record en terme de mariages : avec Grant Chambers, Thorne Forrester, Whipple Jones, Nick Marone, 2 fois avec Eric et pas moins de 6 fois avec Ridge, son grand amour Elle est la mère de Rick, Bridget, Hope, R.J. Kohlberg’s Of Moral. et Jack. Caroline est la fille de Karen Spencer. Ethics Of Christianity. Elle a été élevée par sa mère ainsi que la compagne de cette dernière et n’a fait connaissance avec les Forrester que tardivement. Kohlberg’s Of Moral Reasoning. Ridge et Brooke proposent rapidement un poste à la jeune femme au sein de l’entreprise familiale afin de distraire Rick d’Amber. Of Christianity. Ce qui fonctionne très bien pour Rick mais Caroline, quant à elle, tombe sous le charme de Thomas. Mama Come Home. Lorsque Ridge donne une promotion à ce dernier au lieu de Rick, Caroline constate des changements chez Thomas et se tourne vers Rick. Of Christianity. Plus tard, ce dernier la quitte pour Maya. Essay. Caroline se révèle très ingénieuse et met tout en œuvre pour le récupérer.

Elle parvient à ses fins et se marie finalement avec Rick. Carter est le frère adoptif de Marcus. Ethics. Il est arrivé à Los Angeles pour lui rendre visite mais a fini par accepter un travail chez Forrester Creations. Zsa Zsa Gabor. Immédiatement attiré par Maya, il rejoint le casting d’une web série pour se rapprocher d’elle. Ethics Of Christianity. Ils finissent par sortir ensemble mais après de multiples trahisons de la jeune femme, avec Oliver et Rick, il la laisse tomber et prend sa revanche le jour où l’on apprend qu’elle est en réalité transgenre.

Donna est la sœur cadette de Brooke et l’aînée de Katie. Does Volcanoes. Après une relation tumultueuse avec Thorne, elle quitte Los Angeles pour ne revenir que des années plus tard. Of Christianity. Elle tombe alors amoureuse de Ridge mais comprend rapidement que celui-ci sera toujours lié à Brooke. African American Movies. Pour se venger, elle s’engage alors dans une nouvelle relation avec Thorne, qui échoue à nouveau, puis avec Eric, qui divorce de Stephanie pour l’épouser. Ethics. C’est ainsi que commence sa longue guerre avec Pam, la sœur de Stephanie. Stages Reasoning. Le mariage se solde par un divorce et Donna épouse Justin Barber avec qui elle a un fils : Marcus. Ethics. Peu de temps après, Donna se sépare également de Justin, mais tous deux décident de rester amis. Mama Come Home. Après le décès de Stephanie, elle réconforte Eric et se fait une ennemie en la personne de Quinn

Eric est le patriarche de la famille Forrester et le fondateur de l’empire haute-couture Forrester Creations . Of Christianity. Présent depuis le début du soap, en 1987, il est l’époux de Stéphanie depuis le tout premier épisode jusqu’au décès de cette dernière, en 2013. Zsa Zsa Gabor. Ce qui ne l’empêche pas de commettre de nombreuses incartades au fil des années dont Brooke et Taylor ne sont que les plus renommées ! Il est le père de Thorne, Kristen, Felicia, Angela, Rick et Bridget, et le père adoptif de Ridge. Hope est la fille de Brooke et de Deacon Sharpe, qui n’est autre que l’ex beau-fils de cette dernière. Ethics Of Christianity. Il s’agit d’une jeune femme douce, raisonnable et un brin conservative, à l’inverse de sa mère. Marketing Essay. Après avoir de justesse échappé à un viol, elle se promet d’attendre avant de se donner à l’homme qu’elle aime. Ethics. Elle fait alors la connaissance d’Oliver mais Steffy ne tarde pas à se dresser en travers de leur chemin. Does Have Volcanoes. Sans parvenir à le séduire, elle s’arrange pour détruire leur relation et fait tout pour humilier la jeune femme. Ethics Of Christianity. Par la suite, Hope rencontre Liam et tous deux tombent amoureux. Kohlberg’s Stages Reasoning. Hélas, une fois encore, l’ombre de Steffy jette un voile sur leur relation.

Hope désire se préserver jusqu’au mariage et Steffy en profite pour séduire Liam. Ethics Of Christianity. Au départ, il ne s’agit que de manipulation de la part de cette dernière, mais par la suite, elle développe de vrais sentiments pour Liam et un long triangle amoureux se met en place. Australia Have. Après bien des souffrances de part et d’autre, des unions et des séparations, Liam retrouve Hope et Steffy s’envole pour Paris. Ethics Of Christianity. Mais l’arrivée de Wyatt, le demi-frère caché de Liam, vient une nouvelle fois tout perturber. Does Australia. Fou amoureux de Hope, il fera tout ce qui est en son pouvoir pour la séparer de Liam et parvient à ses fins avec le concours de Steffy, revenue de Paris.

Mais Liam n’a aucune intention de laisser tomber et continue à tout faire pour regagner le cœur de Hope, qui éprouve de son côté des sentiments pour les deux garçons. Of Christianity. Sans compter que Wyatt et sa mère, Quinn, ont de nombreux secrets et sont également des as de la manipulation Katie est la plus jeune des sœurs Logan. Strategy Essay. Elle a fait des apparitions récurrentes dans le soap jusqu’en 2007, où elle devient l’un des personnages principaux. Of Christianity. Depuis que Storm, son frère, lui a tiré dessus avant de se suicider pour lui offrir son cœur, elle a une santé fragile. Essay Reform. Après une relation mouvementée avec Nick, elle tombe amoureuse de Bill. Of Christianity. Mais elle n’est pas au bout de ses peines car il s’avère terriblement manipulateur et infidèle. African American Romance Movies. Malgré tout, lorsque la vie de la jeune femme se trouve en danger, il comprend qu’il éprouve des sentiments profonds et sincères pour elle. Ethics Of Christianity. La jeune femme a également eu une relation avec Ridge, le mari de Brooke, après la trahison de cette dernière avec Bill.

Katie est la mère de Will. Après la mort de sa mère (Kelly Hopkins), Liam emménage à L.A. Zsa Zsa Gabor. pour retrouver son père biologique, Bill. Ethics. Avec le soutien de Hope, qui est rapidement devenue son amie, il se rapproche de ce dernier. Mama Come Home. Plus tard, Amber tente de lui faire croire qu’il est le père de son enfant mais Liam, profondément amoureux de Hope, refuse ses avances. Ethics Of Christianity. Il se rapproche également de Steffy qui exerce sur lui une tentation constante tandis que sa fiancée désire se préserver jusqu’au mariage, ignorant que la jeune femme le manipule pour les séparer. Zsa Zsa Gabor. C’est ainsi que commence un dangereux triangle amoureux. Ethics Of Christianity. En effet, Liam va s’apercevoir qu’il est amoureux des deux jeunes femmes et ces dernières vont s’arracher sa préférence sans merci.

Finalement, Steffy part pour Paris lorsqu’elle apprend qu’elle est stérile et Liam retrouve Hope. Kohlberg’s. Pour peu de temps car son demi-frère, Wyatt, qui vient de faire son apparition, va lui aussi tout tenter pour gagner le cœur de la jeune femme, ce qui va donner lieu à une guerre entre les deux garçons. Of Christianity. Liam perd alors Hope mais refuse de se résigner Maya est une jeune femme très mystérieuse. Does Australia Have Volcanoes. Elle débarque à Los Angeles à sa sortie de prison pour un crime qu’elle n’a pas commis, pour retrouver Dayzee, qui l’a aidée avant son incarcération à faire adopter son bébé. Ethics. Elles apprennent rapidement que celui-ci est mort dans un accident. Reform. Maya fait connaissance avec Rick et commence à travailler pour Forrester Creations. Ethics Of Christianity. Ils entament une relation mais Caroline va tout faire pour y mettre un terme avec l’aide de Bill. Australia. Ils parviennent à leurs fins lorsque Maya trompe Rick avec Carter, son partenaire dans la série qu’elle tourne. Of Christianity. Plus tard, tous deux se fiancent mais Maya est toujours amoureuse de Rick, à présent marié à Caroline. Marketing Essay. Elle est également très attirée par Oliver.

Plus tard, elle retrouve Rick, son grand amour, mais elle a une confession de taille à lui faire : elle est en réalité transgenre Dominick Nick est le fils de Massimo et de Jackie Marone, et donc le demi-frère de Ridge. Of Christianity. Ancien capitaine de bateau, il est directeur de Jackie M Designs. Mama Come Home. Dès son apparition dans la série, il développe des sentiments pour Brooke qui vont créer une rivalité entre Ridge et lui. Of Christianity. Malgré tout, il finit par épouser Bridget, la fille de Brooke, Brooke elle-même assez brièvement, puis Taylor, avec qui il a un enfant : Jack. Kohlberg’s Stages. Mais ce dernier est en réalité le fils biologique de Brooke Pam est la sœur de Stephanie. Ethics. Toutes deux ont passé des années sans contact car, suite aux abus de son père, Stephanie avait coupé les ponts avec sa famille. Movies. Elle invite pourtant Pam à s’installer à Los Angeles et lui demande de garder un œil sur Eric, qui est alors dans la ligne de mire de Jackie Marone. Ethics. Malgré quelques ressentiments, Pam va apporter un soutien indéfectible à Stephanie tout au long de sa maladie ou de ses problèmes avec Eric, notamment lorsque ce dernier a une relation avec Donna, son ennemie, avec qui elle va pourtant devoir travailler, à l’accueil de Forrester Creations ! Récemment, Pam et Charlie, un agent de la sécurité, ont débuté une relation. Quinn est une femme mystérieuse et secrète.

Elle est à la tête de Quinn Artisans Jewelry, une entreprise qui créé des bijoux et qui est associée à Forrester Creations. Zsa Zsa Gabor. C’est également la mère de Wyatt, qu’elle a eu avec Bill à qui elle a jusqu’ici caché l’existence de son fils. Of Christianity. Manipulatrice, Quinn va faire tout ce qui est en son pouvoir pour séparer Liam et Hope avant de se mettre en tête de conquérir Eric, puis Bill. Stages Of Moral. Elle épousera finalement Deacon Sharpe. Rick Forrester est le fils aîné de Brooke et d’Eric.

Depuis toujours, il est jaloux de Ridge et de sa relation avec son père ainsi que de sa position au sein de Forrester Creations. Ethics. C’est pourquoi il a toujours mal vécu la relation de ce dernier avec sa mère et n’a pas n’hésité à séduire ses filles, Phoebe puis Steffy, et enfin Taylor, leur mère. Volcanoes. Par la suite, il fait la connaissance de Caroline Spencer avec qui il débute un long chassé-croisé amoureux. Ethics Of Christianity. Suite au départ de Ridge à Paris, Eric lui confie la présidence de la société au grand dam de Thomas et lui en laisse les rennes, même après le retour de son aîné. Mama Come Home. Il tombe également amoureux de la mystérieuse Maya, ce qui va attiser la jalousie de Caroline. Ethics Of Christianity. Après une brève relation avec la première, il épouse finalement la deuxième. Have. Mais ses sentiments pour Maya ne sont pas tout à fait éteints Ridge est un personnage incontournable de Top Models.

Pendant très longtemps incarné par Ron Moss, il apparaît aujourd’hui dans la série sous les traits de Thosten Kaye. Ethics. Il est l’aîné des enfants d’Eric et Stéphanie et le petit favori de son père, jusqu’à ce qu’il découvre, assez tardivement, qu’il est en réalité le fils de Massimo Marone et donc le demi-frère de Nick ! Designer de talent, le playboy travaille lui aussi pour Forrester Creations. Reasoning. Son cœur a longtemps balancé entre Taylor et Brooke, le grand amour de sa vie. Of Christianity. Il est le père de Thomas, Steffy, Phoebe, R.J. Kohlberg’s Stages. et le beau-père de Hope. Steffy est la fille de Ridge et de Taylor, la sœur de Thomas et la sœur jumelle de Phoebe. Of Christianity. Elle apparaît comme un personnage fort et provocant mais très souvent aussi vindicatif et cruel. Movies. Sa personnalité de garce s’explique par une jeunesse difficile : en effet, elle a été kidnappée par l’ex de son père, sa mère a été laissée pour morte pendant des années et sa sœur jumelle est décédée dans un accident de voiture.

Depuis sa tendre enfance, elle voue une haine immense à Brooke et sa fille, Hope. Ethics. Diaboliquement intelligente, elle fait tout ce qui est en son pouvoir pour les pousser hors de Forrester Creations en séduisant Bill, pour réunir Ridge et Taylor, et enfin, pour voler le petit-ami de Hope, qu’il s’agisse d’Oliver ou de Liam, dont elle va finalement tomber amoureuse. Strategy. Elle n’aura de cesse d’interférer dans la relation sentimentale de ce dernier avec Hope et finira par épouser le jeune homme, mais suite à un accident qui la laisse stérile, elle part pour Paris et le laisse à Hope. Ethics. Pour quelques temps en tous cas Stephanie est l’un des piliers de Top Models. African Movies. Elle a partagé la vie d’Eric pendant la plus grande partie de la série et a eu cinq enfants avec lui : Thorne, Kristen, Felicia, Angela, décédée très jeune, et enfin Ridge, dont le père biologique est en réalité Massimo Marone. Ethics. Mais la relation la plus tumultueuse vécue par Stephanie est sans doute celle qu’elle a entretenue avec Brooke, son ennemie jurée des années durant et l’épouse de ses deux fils, Thorne et Ridge, qui va pourtant devenir une véritable amie à la fin de sa vie. Australia. En vraie matriarche, elle a mené sa famille d’une main de fer, sans hésiter à passer sous silence tout ce qui aurait pu la détruire : la maladie d’Angela, l’identité du vrai père de Ridge, ou encore son propre cancer des poumons À présent décédée, elle a néanmoins marqué de manière indélébile l’esprit de tout son entourage. Thorne est le plus jeune des fils d’Eric et Stephanie. Ethics Of Christianity. Souvent jaloux de Ridge, il parvient d’ailleurs à épouser Caroline, le premier amour de ce dernier.

Plus tard, il épouse Brooke puis Macy et Darla avec qui il a une fille : Alexandria Aly . Reform. Il occupe une place importante au sein de Forrester Creations mais suite à une confrontation avec Ridge, Eric lui retire la présidence de la société. Ethics. Plus tard, lorsque Steffy partage les parts de la société, Thorne est à nouveau mis à l’écart et il part à l’étranger. Zsa Zsa Gabor. À son retour, il est nommé directeur de Forrester International. Wyatt est le fils de Quinn Fuller et de Bill Spencer, et donc le demi-frère de Liam, son grand rival. Ethics. Il a été élevé par sa mère et n’a fait connaissance avec Bill qu’à l’âge adulte, grâce à Hope. Zsa Zsa Gabor. Compétiteur et sûr de lui, il ne reculera devant rien pour gagner le cœur de cette dernière, quitte à partir en guerre contre son frère. Ethics Of Christianity. Mais il est sincèrement et profondément amoureux de Hope, qui fait ressurgir le meilleur en lui. Oliver est le jeune frère d’Agnès. Reasoning. À son arrivée à L.A., il trouve un travail de DJ et fait connaissance avec Hope qui lui plait beaucoup. Ethics Of Christianity. Mais Steffy est déterminée à s’immiscer dans leur relation afin d’avoir le dessus sur la famille Logan.

Elle ne parvient pas à gagner le cœur d’Oliver mais apprend qu’il a eu, par mégarde, une aventure avec Brooke et se met à faire chanter cette dernière. Have. Il perd finalement la jeune femme au profit de Liam, son grand amour. Of Christianity. Il a par la suite une relation avec Amber, pour rendre Hope jalouse, sans succès. African Movies. Il est embauché au sein de Forrester Creations en tant que photographe et fait ainsi connaissance avec Maya et Aly. Ethics Of Christianity. Il utilise tout d’abord cette dernière pour son nom mais finit par éprouver des sentiments pour elle. Ivy est la nièce d’Eric et la fille de John et Claire, sa seconde épouse. Stages Of Moral. Elle est donc la demi-sœur de Jessica Forrester. Ethics Of Christianity. Elle a grandi en Australie (à l’instar de l’actrice), auprès de sa mère. Of Moral Reasoning. Créatrice de bijoux de talent, elle est très rapidement embauchée chez Forrester Créations par Rick et Eric, afin de remplacer Quinn, alors qu’elle rendait simplement visite à sa famille. Ethics. Elle s’installe donc à Los Angeles et commence à travailler aux côtés de Wyatt, avec qui elle entretient de très bons rapports.

Elle devient également l’amie de Liam et le soutient lorsque Hope épouse finalement son demi-frère, suite à un épisode clef à Paris, au cours duquel la jeune femme a fait une chute dans la Seine. African Romance. Elle entame ainsi une relation avec Liam et devient la grande rivale de Hope dans le cœur du jeune homme. Ethics. Mais Hope, à présent mariée à Wyatt, décide de lui rester fidèle. Australia. Suite à une fausse couche, elle part pour Milan, laissant ainsi le champ libre à Ivy pour mener une vie heureuse auprès de Liam. Ethics Of Christianity. À moins qu’une certaine Steffy ne fasse justement son grand retour, bien déterminée elle aussi à le reconquérir Nicole est la petite sœur de Maya. Australia Volcanoes. Elle a grandi avec ses parents dans l’Illinois, avant de débarquer à Los Angeles. Ethics Of Christianity. Elle se présente chez Forrester Créations et prétend être étudiante à UCLA, alors qu’en réalité elle a laissé tomber ses études et rêve de devenir mannequin.

Inspirée par le succès de Maya depuis qu’elle a quitté le domicile familial, elle souhaite tenter sa chance à son tour dans l’industrie de la mode et nouer des liens avec sa sœur. Of Moral Reasoning. Celle-ci, cependant, se montre sur la réserve et ne semble guère enthousiaste à l’idée de passer du temps avec Nicole. Of Christianity. Pensant bien faire, Rick propose à la jeune fille de s’installer dans la maison Forrester. American. Il ne se doute pas à ce moment-là que Nicole détient un secret sur Maya qui pourrait bien chambouler leur vie Elle n’hésite pas, d’ailleurs, à s’en servir pour forcer sa grande sœur à lui offrir un travail chez Forrester. Deacon est le père biologique du Petit Eric , le bébé élevé par Amber et Rick. Ethics Of Christianity. Il tombe d’ailleurs amoureux de la jeune femme, mais ne parvient pas à gagner son cœur. Essay On Tax. Il entame ensuite une relation sentimentale avec Bridget, qu’il finit par épouser. Ethics. Hélas, leur relation ne dure pas car il éprouve toujours des sentiments pour Amber et qu’il finit par trouver du réconfort entre les bras de Brooke, la mère de la jeune femme.

C’est de leur union que naît alors Hope. Zsa Zsa Gabor. Deacon épouse ensuite Macy Alexander qui décède un peu plus tard, avant d’avoir une aventure avec Jackie Marone. Of Christianity. Suite à un nouvel échec sentimental, il quitte la ville. Does Australia Have. Quelques années plus tard, il réapparait à Genoa City, où il tente une nouvelle fois de conquérir Amber en faisant chanter son petit-ami. Of Christianity. Il finit en prison et, une fois libéré, il flirte avec Nikki, Phyllis et Victoria Newman. Zsa Zsa Gabor. Il épouse Nikki à Las Vegas, après une relation tumultueuse. Ethics Of Christianity. Suite à une énième rupture douloureuse, il écope d'une nouvelle peine de prison. Mama Come Home. C’est là que, quelques années plus tard, Bill vient le trouver afin de passer un marché avec lui : sa liberté en échange de son aide dans son plan pour séparer Hope et Liam. Ethics Of Christianity. En dépit de ses hésitations, Deacon finit par accepter et provoque alors l’échec du mariage en Italie. On Tax. Il disparaît de nouveau avant de faire sa réapparition dans le bar où Quinn, qui vient d’être mise à la porte de chez Forrester Creations, noie son chagrin. Of Christianity. Il accepte de l’aider dans son plan pour réunir Wyatt et Hope en échange d’un lieu où habiter.

Plus tard, il regrette d’avoir voulu intercéder dans la vie sentimentale de sa fille, d’autant que celle-ci le prévient que s’il poursuit une relation sentimentale avec Quinn, elle pourrait ne plus jamais vouloir le revoir. Mama Come Home. Après une tentative de suicide de la mère de Wyatt, leur relation devient plus sérieuse. Ethics Of Christianity. Mais le retour de Brooke, à qui Deacon apporte son soutien dans son combat contre son alcoolisme, menace leur bonheur. Does Australia Have Volcanoes. En dépit de la tentation de cette dernière, Deacon demande Quinn en mariage.

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The College Essay as an ethics of christianity, Early Memoir. Occasional reflections on the admissions process by Caren Osten Gerszberg, the mama come home, mother of a high school junior. Last weekend, I participated in a weekend writing workshop. In a sun-filled room overlooking the ethics of christianity, Berkshires, I sat amid 30 or so other writers for two days, as we talked, listened, read and practiced the art of memoir writing. On the first day of the australia have, workshop, Dani Shapiro, the of christianity, author who led the workshop, talked about inspiration, memory and the ways to enter into the telling and in our case, writing of a story. There I sat, struggling to put parts of my story onto paper.

Into what incident, relationship or place did I want to Zsa Zsa Gabor delve? How would it feel to unlock something that resides within me? How would readers feel when they interpret my words? At one point, I looked out the window and ethics, the notion of the african movies, college essay popped into ethics of christianity, my mind. Does Have! I suddenly realized that when these 17-year-old college applicants are drafting their personal statement, they are indeed writing a short form or a portion of their memoir. My daughter, Nicole, has been giving thought to her college essay since her 11th-grade English teacher assigned students to write four different essays in that vein. Id read the ethics, drafts of those essays, and was touched and amused by mama come home the subjects her heritage, middle name, love of storytelling, and a ropes course experience she chose, remembered and recounted.

Over these last several weeks of summer vacation, Nicole has been working, and working some more, on her common application essay. Shes gone back and forth between two ideas, trying to ethics perfect both, hoping that the one she ultimately chooses will best reflect who she is. Her essay will not be an account of her accomplishments, but rather a piece of herself that reveals itself on paper. Reorganizing my office this summer and digging through years of files and papers was part of my summer agenda. And in doing so, I came upon my own college essay. Although it was interesting and emotional to read, I wasnt too impressed with the end result. The topic was my grandfather a Holocaust survivor and all that Id learned from his passions and ability to Reform appreciate life after surviving the atrocities of a concentration camp. My grandfather has planted a seed in me which contains positive emotions of life and all it comprises. This seed will grow, and of christianity, I will pass it on to others so that the world will produce more people who appreciate lifes offerings.

My grammar was surprisingly strong, but the reasoning, writing felt, upon rereading, repetitive and ethics of christianity, unsophisticated. I dont even recall showing it to anyone before sending it off; maybe it would have been better if I had. Im not sure that writing a personal essay or memoir is ever easy. We set out to Essay tell a story, and hope that our readers will be able to identify with, or relate to our story, or perhaps just take something away upon which to ethics of christianity reflect. While I sat in my safe haven last weekend, I listened intently as people in mama come home the room read portions of what may one day make it into their memoir should they choose to write one or may have been perhaps a part of of christianity, their college essay. Some exposed personal tragedies, relationships gone awry, and life-changing revelations. Others shared snippets of lifes mundane moments that nevertheless left a lasting impression. It felt liberating to be, and mama come home, write, in ethics of christianity such an environment. For Nicole and Marketing Strategy Essay, her fellow applicants, however, the ethics of christianity, slice of their story will be writing of another realm. The pressure is on to produce a personal statement that is simultaneously unique, heartfelt, illuminating and entirely impressive.

This will be their chance to mama come home give a very different set of ethics of christianity, strangers an opportunity to african romance turn the pages of their memoir, perhaps the most important one theyll write for a long time. To offer your thoughts on what Ms. Gerszberg has written, please use the comment box below. To read more by her, click here. Comments are no longer being accepted. My daughter, now a sophomore at Penn, completed her college applications and essays without allowing anyone to review them especially her parents. Ethics Of Christianity! Shes always been independent (stubborn?) and this followed the pattern she established early in her childhood. I viewed her applications as truly authentic in the sense that they werent polished and proofed by american romance movies teachers, counselors, and hired consultants. Im sure there were flaws in the writing and misspellings (she is dyslexic), but somehow the genuine person came through.

Of course it made me nervous. Of course I thought my help was needed. But truly it wasnt; the best thing is that she completely owned the ethics of christianity, process, and the result. Zsa Zsa Gabor! She did it herself, and thats the ethics, most valuable outcome for an 18 year old setting out into Zsa Zsa Gabor, the world. Wouldnt it be wonderful if we could stop the ethics of christianity, frenzy and let the Zsa Zsa Gabor, kids do this on ethics of christianity, their own? Wouldnt it be wonderful if they could explore who they are during adolescence instead of compiling resumes of kohlberg’s, activities they dont care about but look impressive on a college application? And wouldnt it be wonderful if they learned that their authentic selves are good enough without a bunch of of christianity, adults pushing them to be something else? My advice is to trust them enought to let go; let them own the process. Sure they will make mistakes.

Sure they will suffer disappointments. But what better preparation could they have for life? As a college admissions counselor, I read many of these personal essays. Kohlberg’s Stages! They are by turn funny, touching and sometimes awkward. Ethics! It is hard to consider such efforts as a memoir because truly a 17 year old has so little of life to reflect on. For the most part, we view an essay as something that a student can use to demonstrate that they can write something that adds another dimension to mama come home the black and white statistics reflected by their high school transcript and standardized test scores. Although it is important to spell all the words right and for ethics goodness sake get the name of the does australia have volcanoes, institution correctly the ethics, rest should not be a source of angst for these students. Write something that sounds like you and it will stand up for mama come home itself. Writing the college essay can be difficult because it is so unlike any other writing assignment that a high school student has ever done.

They are told to ethics of christianity be witty, descriptive, and engaging, but at the same time they are trying to sell themselves and their personality to a committee of strangers. We find that as long as students pick one anecdote, tie it to past accomplishments and future aspirationsalmost any topic can make a great essay. Still, it is hard to convince many students not to re-write their resume with paragraphs or write all about american, their role model in life without ever divulging much about themselves. College essays are great practice for of christianity that future professional balance between humility and self-promotion. It is really wonderful when we see a student embrace a well-chosen topic. While writing a college essay can be difficult, I actually liked writing my essays, especially the one I submitted as part of the common application (and used for mama come home five or six schools). The key for me, was writing the essay on my terms. I planned it, but not too far in ethics of christianity advance that the topic was no longer personally relevant.

I revised and rewrote it, but I never let my parents or anyone else see it. (I just trusted myself and didnt want my voice to be changed as result of others editing.) In fact, when I left an edited copy near the printer, my dad asked if I had left it there for him to edit. I chose a topic that was significant to me, an injury that ended my varsity high school sports career. When I got to australia have volcanoes college and starting working with the admissions office, I heard one of the deans suggest that students specifically not write about injuries. According to her, injuries, like the death of a grandparent, are commonly written about. She explained to of christianity a group of parents and prospective students, that, by in large, teenagers have many of the Zsa Zsa Gabor, same significant life experiences. If you choose one those topics, which many students do, its even harder for ethics your application to stand out. I like to does australia think that mine did stand out, but who knows? Congratulations on a great article! I think students write about such topics as injuries and the death of a grandparent because there is very little else in their mundane teenage lives that forces them to reflect in ethics the way these experiences do. Some of the other experiences a teen may have had , however life-shaping(unwanted pregnancy, for instance), may be just too painful and private to write about.

My own daughter is who she is in part because of some unique experiences that she simply doesnt talk about. I know what they are because I experienced them along with her, but she is a very private person (as I am) and shares very little about how she feels about them. She hates to be under a spotlight, and would probably end up choosing a common essay topic that would not force her to stand out. My daughter was fortunate to Zsa Zsa Gabor be accepted by her first choice college and has begun her freshman year. While reading Ms. Gerszbergs musings I recalled my own experiences with my daughters application process. I was most struck by the requests for the students to ethics of christianity share their innermost thoughts and feelings about themselves and mama come home, loved ones. This was followed up with requests for the familys complete financial status, down to of christianity the penny. In short, everything is shared. Then the student, who has bared her very soul to the anonymous admissions officers, receives a nice but generic rejection letter.

Ultimately the students are accepted somewhere, matriculate, and succeed. However, I cant help wondering about the kohlberg’s of moral reasoning, lingering effects of ethics, this one sided courtship. I think we quickly put it to rest and celebrate the remainder of the senior year, the african american romance movies, graduation, the final summer, the countdown to matriculation day, and ethics of christianity, the ride back home from college without the child. Still, as I feel parental pride and share my daughters joy with this next step in her life, I think there is something very wrong with this process that is not fully appreciated. Perhaps she can write about it in african american movies her personal statement for ethics graduate school. re: Over these last several weeks of summer vacation, Nicole has been working, and working some more, on her common application essay. Reasoning! Shes gone back and forth between two ideas, trying to perfect both, hoping that the one she ultimately chooses will best reflect who she is. If Nicole can give herself permission to ethics spot the deeper, unexpected, but always there connection between her two separate essays, shell see that she can meld them into one self-defining piece of on Tax, writing of ethics, inestimable power and supremely serenity-eliciting satisfaction. You too, for that matter, with your own writing. What are colleges looking for? People who dont care what theyre looking for.

Thats what the amazing process of does australia have volcanoes, writing a college essay is really all about. Interesting article. Heres an interesting link to actual essays, some of which may surprise you. I find it difficult to buy the idea that editing or advice removes a writers voice. Good editing does not, or else published prose wouldnt show its authors style. Of Christianity! The editing is too heavy-handed if a persons voice cant be heard. Its like polishing a piece of figured silverthe polish makes the figures clearer and sharper, but doesnt efface them. I wrote two essays one generic, and mama come home, the other highly personal, which I didnt show anyone because I didnt feel I could. Ethics! In the end, I decided to send the personal one, even though it hadnt been vetted. I got into my reach school without having the best grades or scores; I think the Marketing Strategy Essay, essay must have stood out in the sea of this-experience-made-me-a-better-person essays.

I also work with a company that does a lot of college counseling for high school students, and ethics of christianity, specifically student athletes who are hoping to play a sport at that school, and mama come home, maybe even use that extra curricular passion to leverage them in the admissions process. We also have ex-college admissions officers on ethics, board who have read a lot of essays. We have all come to the conclusion that the essay is one of the most important pieces in the college admissions process. In many cases it is the only way to personalize yourself (especially when there is no interview) to does australia have the admissions officer, and show your character. Many folks say that the essay should by no means be a memoir. Ethics Of Christianity! It is Zsa Zsa Gabor, much easier for the writers character to ethics be conveyed if they show a glimpse or a peek through the curtain of their life, instead of the whole picture. Also, essays about lessons learned can be great for showing that, but discussing a major turning point in ones life can often be forced when coming from someone so young. Athletes writing about of moral, their passion for sports is of christianity, rather taboo. But on the other hand, writing about any other extra curricular activity or hobby (such as knitting mentioned above) would be a great way to show an officer something interesting about yourself that would never show up on the transcript.

I also do not envy the kids applying to colleges these days. Marketing Strategy Essay! On one hand they should be enjoying their last year of highschool, and on the other hand they are making a decision that will not impact the next 4 years of their life, but the ethics, next 40 years. While most big public universities require an essay, I wonder how important that essay is for a student that fits easily into the admission requirements. It seems like it is Essay, not important at ethics of christianity, all really and its a shame that kids who are going this route are made to african american romance waste time with this nonsense. When the university we expect our kids will attend had to ban letters of recommendation (because they were aiding disasterous violations of the public trust) I cheered. One less stress on seniors in the application process. Ms. Gerszberg I was so pleased to read your commentary on the essay as memoir.

After reading so many applications, as an of christianity, independent Admissions Counselor (and former staff counselor), I see this phenomenon daily. But memoirs rarely make good essays. When students try to stages reasoning write authentic accounts of their lives, they often lose sight of their audience: the admissions department. In so doing, they often fail to provide useful information to admissions staff, telling about friendships made, love lost, desires unrequited without how these things relate to ethics college. Admissions folks can make educated guesses regarding how the memoir-like essay translates into a great student at mama come home, their college, but a good essay needs to take you there. Nonetheless, who can resist?

When I was 18 and about to go to college, I wanted (a la Whitman) to sing myself. Its a rite of passage. Ethics! Furthermore, applicants have a reasonable assurance that someone will read their essay, something that a blog or FaceBook cant really guarantee when you really need it. Stages Of Moral Reasoning! Knowing that someone is ethics of christianity, listening and Strategy, listening close enough to evaluate the essays content invites all kinds of tales, many inappropriate. All of this is to say: the ethics of christianity, College Essay Memoir is not usually useful for College Admissionsbut its here to Essay stay. Like any memoir, however, its important to ethics make sure it fits the audience.

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7 Reasons This Is An Excellent Resume For Someone Making A Career Change. Writing a resume can be a daunting task. And if you're changing careers or industries, it's even more challenging. Of Christianity. When you're attempting to change careers, you're often going up against many other candidates who possess a more traditional (and regularly accepted) work history for does australia volcanoes the role or industry you're targeting, says Amanda Augustine, a career expert at TheLadders, an online job-matching service for professionals. But a standout resume will help you get noticed when you might otherwise be passed over. . In order to create an ethics of christianity, eye-catching resume that'll help you stand out from the kohlberg’s stages reasoning, competition, you'll have to look at all your experience and ethics accolades in a different light, she says. Movies. You must evaluate your experience, education, and professional development and skills to determine what's considered important for your new career, and then you'll have to re-position or re-brand yourself. Of Christianity. . To do this, you'll need to become well versed in Essay, your target industry's terminology so you can express your previous experience and of christianity skills in terms that your new audience will understand and Essay appreciate, Augustine explains. That can take a lot of effort on the part of the job seeker; it may even require you to speak with people who work in your target field which you should be doing anyway to of christianity, learn which of american romance, your skills are transferable and most prized.

She says when you have a well-crafted document and an advocate in your corner, you're much more likely to succeed with your career transition. To get a clearer picture of what makes a resume stand out, we asked Augustine to create a sample of an excellent one for ethics a professional changing careers. . While your resume may look different depending on the job or industry you're targeting, the one below from someone hoping to transition from american movies, HR to sales should serve as a useful guide: Skye Gould/Business Insider. What makes this an excellent resume for someone transitioning careers or industries? Augustine outlines the following reasons: 1. The job seeker's new career objective is clear. . If you want to change careers, it's best to have your new job goal well-defined, as this will dictate how you reposition your experience and which qualifications you decide to highlight in your new resume, Augustine says. Of Christianity. . 2. This resume focuses on the skills, achievements, and qualifications that are most relevant to the job seeker's new career track. Mama Come Home. . Ethics. While HR and sales may not seem like similar career tracks, many of the skills leveraged by recruiters can be transferable to a sales or marketing career, she explains. Marketing Strategy. It's important to of christianity, identify which of your skill sets are valuable to another field, and in what capacity. I can rattle off a list of common skills that are easily transferable to Zsa Zsa Gabor, a variety industries and functions problem-solving, strategic thinking, strong written or oral communication, people management, innovation, negotiation, etc. but it gets trickier when you're considering a switch from a very specialized role to ethics, a completely different field.

In these cases, talk to people who work in the industries that interest you. Once they have a good understanding of your background and strengths, they'll be able to provide insight into stages reasoning, which roles in their field might be relevant to you. 3. Ethics Of Christianity. This resume sells what the job seeker has to offer. . Hazel is a technical recruiter seeking a position selling recruiting software to american movies, corporations, so her extensive knowledge of the recruitment process and her experience using and training others on various social recruiting platforms and applicant tracking systems work is emphasized in her professional summary and highlighted throughout the rest of ethics of christianity, her resume. 4. The job seeker's experience is repackaged into terms that her target prospective employers will understand. . Zsa Zsa Gabor. Wherever possible, this job seeker's experience was translated into sales terminology, says Augustine. For example, the terms 'clients' or 'internal clients' were used to describe the hiring managers. Candidates were turned into prospects or potential leads. In her list of ethics, core competencies, 'Hazel' used sales keywords such as 'lifecycle management' and 'pipeline management,' leaving out the terms that would make these competencies recruiter-specific (i.e. 'recruitment process lifecycle' and 'candidate pipeline'). . African American Romance Movies. Every field has its own acronyms and terminology. It's your job to figure out ethics how to translate your experience and past successes into terms that resonate with your new target audience.

Subscribe to industry-specific publications, conduct informational interviews, and start attending events that are relevant to your target field to gain this insight, and update your resume accordingly. 5. This resume is concise and only includes relevant information. . Even though the job seeker has over six years of mama come home, experience and has worked in at least three positions, her resume is only one page long. Her earlier positions only contain small blurbs about her work with a couple achievements highlighted, Augustine notes. Rather than listing out a laundry list of your skills and ethics experience, carefully select the Marketing Strategy, accomplishments and of christianity responsibilities that will support your current career objectives. 6. The job seeker's major contributions and achievements are quantified . . Include numbers whenever possible, whether you're describing the size of your budget, the number of events you helped organize, or the number of people you managed, to australia have, demonstrate your value to the employer. 7. The job seeker included non-work related skills and activities. . Ethics Of Christianity. Hazel listed her membership in Essay on Tax, Toastmasters, since employers value good communication skills in ethics, their sales employees. Showcase any memberships to professional associations, volunteer work, internships, or other extracurricular activities that allowed you to either leverage relevant skills or exposed you to your target field or industry, Augustine says.. NOW WATCH: 7 smart questions to ask at the end of every job interview. Recommended For You Powered by Sailthru.

7 Reasons This Is An Excellent Resume For Someone Making A Career Change.

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Citizens Against Government Waste America's #1 Taxpayer Watchdog. The Congressional Pig Book is CAGW's annual compilation of the pork-barrel projects in the federal budget. A pork project is a line-item in an appropriations bill that designates tax dollars for a specific purpose in circumvention of established budgetary procedures. To qualify as pork, a project must meet one of seven criteria that were developed in 1991 by CAGW and the Congressional Porkbusters Coalition. The 2017 Congressional Pig Book Summary gives a snapshot of each appropriations bill and details the juiciest projects culled from the complete Pig Book . Jump to an appropriations bill:

Pork-barrel spending is alive and well in Washington, D.C., despite claims to the contrary. For the fifth time since Congress enacted an earmark moratorium that began in fiscal year (FY) 2011, Citizens Against Government Waste (CAGW) has unearthed earmarks in ethics of christianity the appropriations bills. In fact, members of Congress have steadily ramped up the use of earmarks in each year since the initiation of the earmark moratorium. African American Romance Movies. The 2017 Congressional Pig Book exposes 163 earmarks in FY 2017, an ethics of christianity, increase of 32.5 percent from the 123 in FY 2016. The cost of earmarks in FY 2017 is $6.8 billion, an Essay, increase of 33.3 percent from the ethics, $5.1 billion in FY 2016.

While the increase in cost over does have one year is disconcerting, the 106.1 percent increase over the $3.3 billion in FY 2012, the first year after the moratorium, is ethics, downright disturbing. Publication of the 2017 Pig Book also marks 11 years since the record earmark amount of $29 billion in FY 2006. In order for earmarks to reach that level over the next decade, legislators would need to increase the cost of the items by just $2.3 billion annually. Unfortunately, this is not out of the question given the Essay on Tax, growth over the past five years. That result will be even more likely if members of Congress like Reps. John Culberson (R-Texas), Mike Rogers (R-Ala.), and Tom Rooney (R-Fla.) prevail in their efforts to overturn the moratorium. On November 16, 2016, eight days after an election that was supposed to drain the ethics of christianity, swamp in Marketing Essay Washington, they filed an amendment to modify the moratorium during a House Republican Conference meeting. Speaker Paul Ryan (R-Wis.) proposed a delay of such a vote until the first quarter of 2017.

The issue is still outstanding. In the midst this debate, it is ethics of christianity, important to remember why the moratorium was deemed necessary. The movement gained traction because of a number of factors, including the tireless work of members of Congress such as Sens. Jeff Flake (R-Ariz.) and John McCain (R-Ariz.); high-profile boondoggles such as the Bridge to Nowhere; and a decade of scandals that resulted in jail terms for Reps. Randy Duke Cunningham (R-Calif.) and romance Bob Ney (R-Ohio), and lobbyist Jack Abramoff. The FY 2017 earmarks were again contained in a consolidated appropriations package, which presents its own challenges regarding how the taxpayers money is being spent. Throwing all the earmarks into one large bill makes it more difficult to identify and eliminate the projects than if Congress adhered to regular order and considered the 12 appropriations bills individually. In FY 2017, as in each of the years following the ethics, establishment of the moratorium, there are fewer earmarks than in Zsa Zsa Gabor the peak years, but far more money was spent on average for each earmark and no detailed description was provided. For instance, legislators added 14 earmarks costing $671.5 million for the FY 2017 Army Corps of Engineers in the Energy and Water Development and Related Agencies Appropriations Act.

These earmarks correspond to 482 earmarks costing $541.7 million in FY 2010. In other words, the average dollar amount for the Corps of Engineers earmarks in FY 2017 was $48 million, while in FY 2010 that average was $1.1 million. The Congressionally Directed Spending section at ethics, the end of the Zsa Zsa Gabor, FY 2010 bill contained the names of the members of Congress requesting each project and its location, as required by the transparency rules. In stark contrast, the FY 2017 earmarks, which cost $129.8 million more than the FY 2010 projects, contained no such data and simply created a pool of money to be distributed at a later date without any specific information about the eventual recipients. Members of Congress will argue that their standards differ from the earmark criteria used in the Pig Book , and ethics that the appropriations bills are earmark-free according to their definition. However, the difference in the definition of earmarks between CAGW and Congress has existed since the first Pig Book in 1991.

The pork-free claim can also be challenged based on the inclusion of projects that have appeared in australia have past appropriations bills as earmarks. In addition to meeting CAGWs long-standing seven-point criteria, to of christianity, qualify for the 2017 Pig Book a project or program must have appeared in prior years as an earmark. The total number and cost of earmarks are, therefore, quite conservative. The question for those in Congress who deny the existence of Zsa Zsa Gabor, earmarks in the appropriations bills is: Why were these projects previously considered earmarks, but not in 2017? Unfortunately, the earmark moratorium has not only failed to eliminate earmarks, but also has rendered the ethics of christianity, process patently less transparent. There are no names of legislators, no list or chart of earmarks, and limited information on where and how the money will be spent. Earmarks were scattered throughout the legislative and report language, requiring substantial detective work to unearth each project.

While the lower number and cost of earmarks are an improvement relative to many prior years, transparency and accountability have regressed immeasurably. One of the mama come home, most frequently used arguments in favor of earmarks is of christianity, that they would help pass certain spending bills. Mama Come Home. In the past, however, members have voted for excessively expensive legislation because they have received a few earmarks, which means the moratorium has helped restrain spending. A return to rampant earmarking would inevitably increase the risk of of christianity, corruption and Strategy the potential for an explosion in expenditures compared to of christianity, current levels. There are also concerns regarding which legislators benefit most in a system with openly-incorporated earmarks. As Sen. McCain explained on May 7, 2014, regarding those making the case for a return to earmarks, The problem with all their arguments is: the more powerful you are, the more likely it is you get the Reform, earmark in. Therefore, it is a corrupt system. Earmarks create a few winners (appropriators, special interests, and lobbyists) and a great many losers (taxpayers). They contribute to the deficit directly, by tacking on extra funding, and indirectly, by attracting votes to costly legislation that might not otherwise pass.

Earmarks corrupt democracy by of christianity, eclipsing more important matters in the minds of legislators and stages of moral voters. The 25th installment of CAGWs expose of pork-barrel spending includes $9 million for the aquatic plant control program; $5.9 million for the East-West Center, an of christianity, earmark championed by Senate Appropriations Committee member Brian Schatz (D-Hawaii); and $5 million for Save Americas Treasures grants, which in the past has supported the restoration and operation of theatres, museums, and opera houses. The projects in the 2017 Congressional Pig Book Summary symbolize the does have volcanoes, most blatant examples of ethics of christianity, pork. Reform. As in previous years, all items in the Congressional Pig Book meet at least one of CAGWs seven criteria, but most satisfy at least two: Requested by only one chamber of Congress; Not specifically authorized; Not competitively awarded; Not requested by the President; Greatly exceeds the Presidents budget request or the previous years funding; Not the subject of congressional hearings; or Serves only a local or special interest. Members of Congress have long used the Agriculture, Rural Development, Food and Drug Administration, and Related Agencies Appropriations Act to feed at the trough, and that trend continued this year. The number of earmarks increased by 50 percent, from three in of christianity FY 2016 to six in FY 2017, and mama come home the cost increased by 47.3 percent, from $23.9 million in FY 2016 to $35.2 million in FY 2017. $10,000,000 for high energy cost grants within the Rural Utilities Service (RUS).

The RUS grew out of the remnants of the Department of Agricultures Rural Electrification Administration (REA) of the 1930s. The REAs mission was to of christianity, promote electrification to Marketing Essay, farmers and residents in of christianity communities where the cost of providing electricity was considered to be too expensive for local utilities. By 1981, 98.7 percent electrification and 95 percent telephone service coverage was achieved. Rather than declaring victory and shutting down the REA, the agency was transformed into the RUS, and expanded into other areas. RUS high energy cost grants are intended to assist communities whose energy costs exceed 275 percent of the national average by funding the construction, installation, and repair of energy distribution facilities.

This may sound like a bright idea, but the RUS Electric Loan program is intended to does australia have, achieve the of christianity, same objective. Former President Obamas FY 2013 version of Cuts, Consolidations, and reasoning Savings proposed the elimination of the high energy cost program, noting that low-interest electric loans are available through the ethics, RUS to residents of the areas served by the high energy cost program, which include Alaska, Hawaii, several communities in certain other states, and U.S. territories. Since FY 2002, members of Congress have added seven earmarks for high energy cost grants totaling $123.5 million. $6,000,000 for the Delta Regional Authority (DRA), which also received a $9,064,000 earmark in mama come home the Energy and Water Development and Related Agencies Appropriations Act, for a combined total of $15,064,000, or $2 million more than in FY 2016. The amount earmarked nearly doubled the DRAs budget request of ethics of christianity, $15.9 million for FY 2017. Established in mama come home 2000, the DRA is intended to provide economic development assistance to support the creation of of christianity, jobs and improve local conditions for the 10 million people who reside in 252 counties and parishes throughout the Mississippi Delta states of Alabama, Arkansas, Illinois, Kentucky, Louisiana, Mississippi, Missouri, and australia Tennessee. According to the Republican Study Committees FY 2016 budget, funding for the DRA should be terminated because such regional commissions are duplicative of other federal programs and support mostly local projects. Ethics. Support for cutting DRA funds is bipartisan, as former President Obamas FY 2017 version of Cuts, Consolidations, and Savings recommended reducing the agencys budget by $3 million annually. President Trumps FY 2018 Major Savings and Zsa Zsa Gabor Reforms recommended eliminating the ethics, DRA, the Appalachian Regional Commission, the Reform, Denali Commission, and the Northern Border Regional Commission, saving $156 million. Since FY 2003, the DRA has received 10 earmarks totaling $45.9 million. The Department of Defense (DOD) has received the most earmarks at the highest cost to taxpayers in each year since FY 1994, a trend that continued in FY 2017.

The number of earmarks in ethics the bill rose by 59.7 percent, from Essay 67 in FY 2016 to ethics, 107 in FY 2017. Zsa Zsa Gabor. The cost of these earmarks expanded correspondingly, increasing by 57.6 percent, from $3.3 billion in FY 2016 to ethics of christianity, $5.2 billion in mama come home FY 2017. This total constitutes 76.5 percent of the $6.8 billion in earmarks contained in the 12 appropriations bills for of christianity FY 2017. $1,279,200,000 for 31 earmarks for health and disease research under the Defense Health Program, which is an 11.2 percent increase in cost over the 28 earmarks worth $1,150,800,000 in FY 2016. Former Sen. Tom Coburns (R-Okla.) November 2012 report, The Department of Everything, pointed out mama come home, that the DOD disease earmarks added by Congress mean that fewer resources are available for DOD to address those specific health challenges facing members of the armed forces for ethics of christianity which no other agencies are focused. According to the report, in 2010 the Pentagon withheld more than $45 million for overhead related to earmarks, which means those funds were unavailable for national security needs or medical research specifically affecting those serving in the military.

A March 14, 2012, Washington Post article stated that DOD Comptroller Robert Hale proposed decreasing the Pentagon health budget in part by movies, eliminating one-time congressional adds, which he said totaled $603.6 million in FY 2012 for the Congressionally Directed Medical Research Program. Since FY 1996, members of Congress have added 671 earmarks for the Defense Health Program, costing taxpayers $10.5 billion. $1,020,800,000 for four earmarks funding two planes intended to be replaced by the F-35 Joint Strike Fighter (JSF): $979 million for 12 additional F/A-18 E/F Hornets for the Navy; $24.8 million for F-16 mission training center simulators; $12 million for a missile warning system for of christianity the F-16; and $5 million for anti-jamming GPS for Zsa Zsa Gabor the F-16. The Air Force declared its variant of the JSF to be combat ready in August 2016, 15 years after Lockheed Martin won the contract. However, a report released in the same month by former DOD Operational Test and of christianity Evaluation Director Michael Gilmore found that, achieving full combat capability with the Joint Strike Fighter is at substantial risk of not occurring prior to the end of development. The report described the JSF as not on a path toward success but instead on a path toward failing to deliver. In the interim, those aircraft the JSF is mama come home, meant to replace are aging rapidly, leaving a readiness gap. Ethics. During a February 7, 2017 House Armed Services Committee hearing, Vice Chief of Naval Operations Admiral William Moran claimed that the number of grounded F/A-18s is double where we should be. As of February 2017, 62 percent of the planes were non-operational, and 53 percent of the stages, Navy's total air fleet is of christianity, grounded. Beyond the litany of cost overruns and delays, doubts exist as to whether the JSF will be an american movies, improvement.

Many members of Congress, including Rep. Martha McSally (R-Ariz.), who served 26 years in the Air Force and ethics of christianity retired as a colonel in 2010, have questioned whether the F-35 will exceed the performance of the (far cheaper) A-10 in close-air support of troops on the ground. In addition, a January 2015 simulation which pitted the JSF against Strategy Essay the F-16 found the F-35 to be at a disadvantage in air-to-air combat, according to a leaked test pilots report. $500,000,000 for two additional JSF aircraft for both the Navy and ethics the Marine Corps. The acquisition misadventures of the JSF program have been well-documented. In development for nearly 16 years and six years behind schedule, the program is approximately $170 billion over budget and has encountered an abundance of persistent issues. Have Volcanoes. An April 2015 Government Accountability Office (GAO) report noted that the lifetime operation and maintenance costs of the most expensive weapon system in history will total approximately $1 trillion. Many of the problems with the F-35 program can be traced back to the decision to ethics of christianity, operate program development and procurement simultaneously. Strategy Essay. This meant that whenever problems were identified, contractors needed to go back and make changes to aircraft that were already in production. Speaking at the Aspen Security Forum on July 24, 2015, Air Force Secretary Deborah Lee James stated, The biggest lesson I have learned from the ethics of christianity, F-35 is never again should we be flying an aircraft while were building it. And Under Secretary of Defense for Acquisition, Technology, and Marketing Essay Logistics Frank Kendall referred to the purchase of the F-35 as acquisition malpractice in February 2014.

Remarkably, other DOD brass do not appear overly concerned. On December 19, 2016, Lieutenant General Christopher Bogdan, who heads the ethics, F-35 Program Office, claimed This program is mama come home, not out of of christianity, control. For this stark example of institutional bias, CAGW named Lt. Have Volcanoes. Gen. Bogdan Porker of the Month for January 2017. Rather than asking pressing questions as to whether the JSF remains worthy of ethics of christianity, further commitment, members of american romance, Congress provided an earmark for four additional aircraft.

Since FY 2001, members of ethics of christianity, Congress have added 13 earmarks for the JSF program, costing $2.4 billion. $150,000,000 for two earmarks for the National Guard Counter-Drug Program. Formerly earmarked to individual states and congressional districts, the program, which allows for australia have the use of military personnel in domestic drug enforcement operations, is now funded in of christianity one bundle as a work-around to the earmark moratorium. On Tax Reform. The Drug Enforcement Administration, with a budget of $2.1 billion, is already responsible for these activities. Since FY 2001, there have been 68 earmarks costing taxpayers $642.1 million for the National Guard Counter-Drug Program. Members of Congress who have inserted earmarks for this program in the past include longtime pork advocates such as Senate Majority Leader Mitch McConnell (R-Ky.), House Appropriations Committee member Harold Rogers (R-Ky.), former Senate Minority Leader Harry Reid (D-Nev.), and the late Sens.

Daniel Inouye (D-Hawaii) and ethics Ted Stevens (R-Alaska). $30,000,000 for the Starbase Youth Program, or $5 million more than the Marketing Strategy, amount earmarked in each of the of christianity, past three years. Starbase teaches science, technology, engineering, and math (STEM) to at-risk youth in multiple locations at or near military bases around the Essay, country. Since FY 2001, 10 earmarks costing taxpayers $124 million have been added for Starbase, including an earmark worth $1.9 million in FY 2010 added by Sen. Amy Klobuchar (D-Minn.) and Rep. Keith Ellison (D-Minn.). A March 2012 GAO annual report on program duplication, overlap, and fragmentation found that $3 billion was spent in FY 2010 across 13 agencies for 209 STEM programs, 83 percent of ethics of christianity, which overlapped with at least one other program. Former President Obama proposed the consolidation or elimination of 31 STEM programs in FY 2015, and a further 20 STEM programs in FY 2016.

$15,000,000 for alternative energy research within the Combat Vehicle and Automotive Technology program. Since FY 2004, Congress has used the Defense Appropriations bill as a vehicle to insert 27 earmarks worth $289.9 million for this purpose, despite the fact that the Energy and Water Development Appropriations Act supplies billions of dollars for alternative energy research every year. During a March 13, 2012, Senate Armed Services Committee hearing, then-Ranking Member John McCain (R-Ariz.) asserted that the Navys efforts to develop biofuels could turn into american, another Solyndra situation, citing the solar panel manufacturer that received a $535 million loan guarantee through the Department of Energy before filing for ethics of christianity bankruptcy in September 2011. According to Sen. McCain, the Navy spent in kohlberg’s stages of moral reasoning excess of $400 per gallon for ethics of christianity approximately 20,000 gallons of algae-based biofuel. In a February 2011 hearing, House Armed Services Committee member Randy Forbes (R-Va.) fired a shot across the Navys bow, telling Navy Secretary Ray Mabus, Youre not the Reform, secretary of Energy.

Youre the secretary of the Navy. The Energy and of christianity Water Development and Essay Related Agencies Appropriations Act is of christianity, more flooded with pork than it was in FY 2016. The number of earmarks increased by 9.1 percent, from 22 in FY 2016 to 24 in FY 2017, while the cost surged by 40.6 percent, from $704.7 million in FY 2016 to $991 million in kohlberg’s stages reasoning FY 2017. $671,540,000 for 14 earmarks for the Army Corps of Engineers, a 22 percent increase in cost from the $549.6 million in ethics of christianity FY 2016. President Trumps FY 2018 Major Savings and Reforms recommended reducing the Corps of Engineers budget by $976 million.

Legislators have long treated the Army Corps of Engineers as a prime repository of pork, and it is among the most heavily earmarked areas of the federal budget. Since FY 1996, members of Congress have added 6,916 earmarks for the Corps, costing taxpayers $12.8 billion. Apparently, that is not enough for members of Congress like House Appropriations Committee member Tom Rooney (R-Fla.). On May 4, 2017, he introduced H. Res. 313, which updates the definition of a congressional earmark to australia, permit vetted projects for the Army Corps of Engineers and the Bureau of Reclamation.

While Rep. Rooney claimed in his May 4 press release that this would be good for the country, his true motivation was to obtain the ability to increase funding for two projects in his congressional district. Ethics Of Christianity. He stated he did not want a complete repeal of the earmark moratorium, but the pathology of pork is so pervasive that any change in the earmark definition would never be limited to a particular type of spending. For this hypocrisy, CAGW named Rep. Rooney Porker of the Month for May 2017. $32,000,000 for the Appalachian Regional Commission (ARC), a 37.3 percent decrease from the $51 million in FY 2016.

ARC was created by australia have, Congress in 1965 to bring the 13 Appalachian states into the mainstream of the American economy. The commission represents a partnership of federal, state, and local governments and covers all of West Virginia along with portions of Alabama, Georgia, Kentucky, Maryland, Mississippi, New York, North Carolina, Ohio, Pennsylvania, South Carolina, Tennessee, and ethics Virginia. Strategy Essay. ARC provides funding for several hundred highway and development projects throughout the Appalachian region. The commission is ethics, duplicative of dozens of other programs that exist at the federal, state, and Essay on Tax Reform local levels, and unfairly focuses on a region of the country that is no more deserving than other impoverished areas. Since FY 1995, the ethics, ARC has received nine earmarks totaling $253.5 million for projects in Alabama, Kentucky, and West Virginia. $9,064,000 for the Delta Regional Authority, which also received an earmark costing $6 million in the Agriculture Appropriations Act, for a combined total of $15,064,000. $9,000,000 for the aquatic plant control program, an increase of 12.5 percent from the $8 million earmarked in Reform FY 2016. Since 1994, there have been 23 earmarks worth a total of of christianity, $47.1 million for does aquatic plant control projects, including three by Sen. Chuck Schumer (D-N.Y.) and one each by ethics of christianity, Sens. Patrick Leahy (D-Vt.) and volcanoes Jeff Sessions (R-Ala.).

The FY 2017 version of the Financial Services and of christianity General Government Appropriations Act contained two earmarks, double the Marketing Strategy, amount in FY 2016. Ethics. The cost of these earmarks increased by 3.5 percent, from $56.6 million in FY 2016 to $58.6 million in FY 2017. $57,590,000 for the High Intensity Drug Trafficking Areas program (HIDTA) at the Office of National Drug Control Policy, an increase of 1.8 percent from the $56.6 million earmarked in FY 2016. Originally intended for Southern border states, members of Congress have used earmarks to expand HIDTA to non-border states. Since FY 1997, 31 earmarks costing taxpayers $327.4 million have been provided for stages of moral HIDTA programs; 16 of the earmarks were directed to programs in 10 states, only two of which, Arizona and of christianity New Mexico, are on the Southern border. The other eight states that received HIDTA earmarks were Alabama, Hawaii, Iowa, Louisiana, Missouri, New Jersey, Tennessee, and Marketing Strategy Wisconsin. Former President Obamas FY 2017 version of Cuts, Consolidations, and Savings recommended trimming the HIDTA program by $54 million, or 21.6 percent, from the $250 million spent in FY 2016.

The earmark canceled out that proposed reduction. While the number of earmarks in the FY 2017 Department of Homeland Security (DHS) Appropriations Act remained steady at seven, the cost of the earmarks decreased by 57 percent, from $329.1 million in FY 2016 to $141.6 million in FY 2017. This sharp reduction can be explained by the absence of earmarks for the Port Security Grant Program, which received $100 million in FY 2016, and the Offshore Patrol Cutter, which received a $70.5 million earmark. Members of Congress should be congratulated for reducing the cost of earmarks in the DHS bill, bucking the wider trend in FY 2017. $65,000,000 for the National Domestic Preparedness Consortium (NDPC), which strives to increase the of christianity, preparedness of first responders to the threats of terrorism. The $65 million earmarked in FY 2017 is a 16.1 percent increase over the $56 million in FY 2016. Since FY 2005, the Marketing Essay, NDPC has received seven earmarks worth $480.6 million, including a $10.1 million earmark in FY 2010 by Senate appropriator Tom Udall (D-N.M.) and of christianity former Sen. Jeff Bingaman (D-N.M.). $45,515,000 for the National Predisaster Mitigation Fund (NPMF). Following a one-year absence, the NPMF has returned, with a large increase. The $45.5 million earmarked in FY 2017 represents an 82 percent increase over does australia have the $25 million in of christianity FY 2015.

Former President Obamas FY 2017 Cuts, Consolidations, and mama come home Savings recommended reducing the NPMF by $46 million, nearly matching the ethics, amount earmarked by members of american romance movies, Congress. Ethics. Since FY 2008, there have been 207 NPMF earmarks requested by more than 100 members of Congress, costing taxpayers $196.1 million. The number of earmarks in the FY 2017 Department of the Interior, Environment, and Essay on Tax Reform Related Agencies Appropriations Act increased by 166.7 percent, from three in FY 2016 to eight in FY 2017. Of Christianity. The cost of the earmarks increased by 33.8 percent, from $29.9 million in FY 2016 to Strategy Essay, $40 million in FY 2016. $10,374,000 for the Heritage Partnership Program (HPP), which supports the 49 National Heritage Areas (NHAs) created by Congress. Operated through the of christianity, National Park Service (NPS), the HPP has received 51 earmarks costing $76.5 million since FY 2001, including funding for australia have projects such as park improvements, sports complexes, health centers, water quality monitoring, bike paths, sustainable agriculture, and agricultural tourism. Each of former President Obamas budgets from ethics of christianity FYs 2011-2017 slashed funding for NHAs, including the FY 2017 version of Cuts, Consolidations, and Zsa Zsa Gabor Savings, which recommended trimming the budget by 55 percent, from $20 million to $9 million.

President Trumps FY 2018 Major Savings and Reforms proposed an even bigger cut to $1 million, noting that there is no systematic process for designating Heritage Partnership Areas or determining their effectiveness, and that funding for the HPP diverted resources from of christianity core NPS responsibilities. Unfortunately, members of mama come home, Congress have continuously ignored these proposed budget reductions, earmarking funding for ethics the HPP in every year since FY 2011. $5,000,000 for the Save Americas Treasures (SAT) grants program, which helps preserve historic locations across the country. The earmark is the first for the program since FY 2010. Since FY 2006, there have been 265 SAT earmarks costing taxpayers $55.5 million. The SAT program exemplifies how any exceptions to the earmark moratorium, such as those proposed by Rep. African Romance Movies. Tom Rooney (R-Fla.) for the Army Corps of ethics of christianity, Engineers and the Bureau of Reclamation, will never be limited.

Between FYs 2008-10, when transparency rules required each earmark to contain the name of the legislator who requested it and the recipients name, city, and state, members of Congress went whole hog for SAT earmarks. In FY 2008, 78 members of Congress added 70 earmarks costing $13.6 million. In FY 2009, 58 members of Marketing Essay, Congress added 55 earmarks costing $10 million. And in FY 2010, 72 members of Congress added 52 earmarks costing $10.2 million. During those three years, there were 21 earmarks for theaters costing $4.5 million; 10 earmarks for museums costing $2.4 million; and seven earmarks for opera houses costing $1.5 million. One of those earmarks, worth $150,000, was obtained by Rep. Rosa DeLauro (D-Conn.) in ethics of christianity FY 2010 for the Sterling Opera House in Derby, Connecticut; $110,000 of that amount had to be returned to the federal government after it was improperly used by the city. SAT earmarks contributed to Essay, the downfall of ethics of christianity, former House Appropriations Committee member Alan Mollohan (D-W.Va.). Does Australia Volcanoes. In FY 2010, he added $150,000 for restoration of the Cottrill Opera House through the Vandalia Heritage Foundation, which was operated by ethics, a former aide, Laura Kurtz Kuhn.

This was one of several earmarks that led to Rep. Mollohan being accused of potential ethics violations, a key issue in his primary election loss in May 2010. While the romance, earmarks in ethics FYs 2008-2010 were transparent, there is no indication where the of moral reasoning, FY 2017 earmark is going. As a result, taxpayers will be unaware should a member of Congress direct the SAT money in FY 2017 to a friend, or anyone else. Former President Obama called for the elimination of the SAT program in the FY 2011 version of Cuts, Consolidations, and Savings, to allow the of christianity, NPS to focus resources on Reform, managing national parks and ethics other activities that most closely align with its core mission, since the grants have not demonstrated how they contribute to nationwide historic preservation goals. On top of these problems with the SAT program, many facilities could have simply charged more money or found other ways to match the amount of the earmarks. A prime example is the $147,660 earmarked by Rep. Peter King (R-N.Y.) in FY 2008 for the plush de Seversky Center Mansion in Old Westbury, New York, which brings together Gatsby-era opulence, modern convenience, and highly personalized service for corporate events and weddings. calls the Essay Reform, facility one of the premier event and wedding venues in the New York area and cites the average wedding cost at between $73,015 and ethics of christianity $86,737 for a ceremony reception for 150 guests. In other words, two weddings could have replaced the earmark. Another such facility is the Roberson Center in Binghamton, N.Y., located in the district of former House appropriator Maurice Hinchey (D-N.Y.), which received a $100,000 earmark in FY 2006.

The center raised $50,000 for Zsa Zsa Gabor its 12th annual Wine and Food Fest in 2017, and charges $215 per ethics week for summer camp, which means just 23 more attendees per week for the 10 weeks of camp would equal the remaining $50,000 of the earmark. Members of african, Congress should Save Americas Taxpayers by eliminating this earmark. VII. Labor, Health and Human Services, and Education (Labor/HHS) For the second consecutive year, the FY 2017 Labor/HHS Appropriations Act experienced a significant drop in earmarks. The number of projects in the bill decreased by 55.6 percent, from nine in FY 2016 to four in of christianity FY 2017, while the cost was reduced by 77.8 percent, from $252.6 million in FY 2016 to $56.2 million in FY 2017. Mama Come Home. This total represents a 90 percent decline in cost from the $562.5 million earmarked in FY 2015. $17,409,000 for Rural Hospital Flexibility Grants (Flex) through the Department of Health and Human Services, a 13 percent increase from the $15.4 million earmarked in FY 2016. Flex grants were created to ethics of christianity, improve access to hospitals and other health services for stages families that live in rural communities. The last six Obama administration budgets recommended slashing funding for the Flex program, including by $16 million in FY 2017. In each instance, legislators restored a similar amount of funding via an earmark.

Since FY 2006, Flex grants have received six earmarks totaling $141.7 million. VIII. State and Foreign Operations. The number of earmarks in the FY 2017 State and of christianity Foreign Operations Appropriations Act dropped by 20 percent, from five in FY 2016 to four in FY 2017. Mama Come Home. The cost of the earmarks decreased by 4.1 percent, from $232.4 million in FY 2016 to $222.8 million in FY 2017. $66,500,000 for the National Endowment for Democracy (NED), a private, nonprofit foundation that aims to help grow and strengthen democratic institutions around the world. Since FY 1997, NED has received seven earmarks worth a total of $279.2 million. $5,900,000 for ethics of christianity the East-West Center in Hawaii.

Intended to Essay on Tax, promote better relations with Pacific and Asian nations, the ethics of christianity, center was established by Congress in 1960 with no congressional hearings and over the State Departments opposition. For years, the State Department tried to eliminate the center by not requesting funding in the departments annual budget requests. After Sen. Daniel Inouye (D-Hawaii) passed away in 2013, Senate Appropriations Committee member Brian Schatz (D-Hawaii) took over as the centers champion. In a May 1, 2017, press release, Sen. Schatz claimed credit for securing funding at a level $5.9 million above the Zsa Zsa Gabor, administrations request. The East-West Center is ethics of christianity, similar to the North-South Center, which stopped receiving federal funding in 2001. Does Australia Volcanoes. An April 3, 2009, Congressional Research Service report stated, Congress has not funded the North-South Center since FY 2001, noting that it should be funded by the private sector. Following that logic, the East-West Center should be funded by the private sector as well. It probably would be, except the center is located in of christianity the state of a Senate appropriator. Australia Volcanoes. Since FY 1997, the East-West Center has received 14 earmarks totaling $138.2 million. $5,000,000 for the Asia Foundation, which is committed to improving lives across a dynamic and developing Asia. Since FY 1997, members of ethics, Congress have directed 11 earmarks totaling $64.6 million to african, the Asia Foundation.

The Asia Foundation has a $100 million annual budget, which means the earmark represents 5 percent of its income. The organization had 500 donors between October 1, 2015, and September 30, 2016, composed of 80 corporations and organizations, 37 government agencies, and 383 individuals. Clearly, it is capable of ethics of christianity, raising another $5 million to does australia have, replace the ethics of christianity, earmark. Just like the North-South Center did in 2001 and the East-West Center should do now, the Asia Foundation should rely solely on Strategy Essay, private sources of funding and the earmarks should come to of christianity, an end. IX.

Transportation Housing and Urban Development (THUD) The number of earmarks in the FY 2017 THUD and Related Agencies Appropriations Act decreased by 50 percent, from Strategy two in of christianity FY 2016 to one in FY 2017. The cost dropped by 72.7 percent, from $8.8 million in FY 2016 to $2.4 million in FY 2017. $2,387,000 for advanced materials and structural safety within the Airport and Airways Trust Fund (AATF), through which the Federal Aviation Administration finances infrastructure improvements for airports. According to a November 21, 2016 Cato Institute report, the AATF has the indirect effect of preventing competition among airlines at airports. Because the mama come home, AATF allows for only limited funding for maintenance and ethics improvements, airports are limited in the number of gates they can build.

As a result, airport managers ration gate access through long-term contracts with established companies, creating a barrier to entry for potential competitors. In contrast, according to a 2016 Airport Council International report, market-based reforms in European airports have led to significant volumes of african american, investment in necessary infrastructure, higher service quality levels, and a commercial acumen which allows airport operators to diversify revenue streams and minimize the costs that users have to pay. Because privatized European airports are not forced to ethics, compete with inefficient government-subsidized airport ownership, healthy competition thrives and consumers pay lower prices. This report was written by Sean Kennedy, Director of australia, Research, and Curtis Kalin, Director of ethics of christianity, Communications. It was edited by Thomas A. Schatz, President. CAGW Names Rep. African American Romance Movies. Rodney Frelinghuysen September 2017 Porker of the ethics, Month.

Rep. Frelinghuysen is CAGW's September Porker of the Month for earmarking $900 million for a massive transportation boondoggle.

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Self taught freelance graphic designer and photographer. He loves collecting and showcasing good fonts and typefaces at his blog Fonts Collector.